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Cellosaurus NW145/E7 (CVCL_C538)

[Text version]
Cell line name NW145/E7
Synonyms NW-145/E7; NW145 clone E7
Accession CVCL_C538
Resource Identification Initiative To cite this cell line use: NW145/E7 (RRID:CVCL_C538)
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (from parent cell line).
HLA typing Source: PubMed=15592718
Class I
HLA-AA*23:01,23:01
HLA-BB*15:01:01:01,15:01:01:01
HLA-CC*01:02,01:02
Class II
HLA-DPDPB1*04:02,04:02
HLA-DQDQB1*03:01:01,03:01:01
HLA-DRDRB1*11:01,11:01
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2148 (NW145)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): ESTDAB=ESTDAB-058

Markers:
AmelogeninX,Y
CSF1PO12
D3S135814,15
D5S81811
D7S82010
D13S31711,12
FGA20
TH017
TPOX11
vWA19

Run an STR similarity search on this cell line
Publications

PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966
Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello Osuna F., Dodi I.A., Lopez-Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G., Garrido F.
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005)

PubMed=19340423; DOI=10.1007/s00262-009-0701-z; PMCID=PMC11030131
Mendez R., Aptsiauri N., Del Campo A., Maleno I., Cabrera T., Ruiz-Cabello Osuna F., Garrido F., Garcia-Lora A.
HLA and melanoma: multiple alterations in HLA class I and II expression in human melanoma cell lines from ESTDAB cell bank.
Cancer Immunol. Immunother. 58:1507-1515(2009)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C538
ESTDAB; ESTDAB-058
Encyclopedic resources Wikidata; Q54931192
Polymorphism and mutation databases Cosmic; 972259
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number13