Cellosaurus cell line NW145 (CVCL

Cellosaurus NW145 (CVCL_2148)

[Text version]

Cell line name

NW145

Synonyms

NW-145; NW 145; NW-MEL-145; NW-Mel-145; EST57

Accession

CVCL_2148

Resource Identification Initiative

To cite this cell line use: NW145 (RRID:CVCL_2148)

Comments

Omics: Array-based CGH.

Sequence variations

Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=17260012).
Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=17260012; PubMed=23851445).

HLA typing

Source: PubMed=15592718

Class I
HLA-A	A*23:01,23:01
HLA-B	B*15:01:01:01,15:01:01:01
HLA-C	C*01:02,01:02
Class II
HLA-DP	DPB1*04:02
HLA-DQ	DQB1*06:04,03:01:01
HLA-DR	DRB1*04:01,11:01

Disease

Cutaneous melanoma (NCIt: C3510)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Children:

CVCL_C538 (NW145/E7)

Sex of cell

Male

Category

Cancer cell line

STR profile

Source(s): ESTDAB=ESTDAB-057

Markers:

Amelogenin	X,Y
CSF1PO	12
D3S1358	14,15
D5S818	11
D7S820	10
D13S317	11,12
FGA	20
TH01	7
TPOX	11
vWA	19

Publications

PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966
Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello Osuna F., Dodi I.A., Lopez-Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G., Garrido F.
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005)

PubMed=17260012; DOI=10.1038/sj.onc.1210252
Jonsson G., Dahl C., Staaf J., Sandberg T., Bendahl P.-O., Ringner M., Guldberg P., Borg A.
Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.
Oncogene 26:4738-4748(2007)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L., Borg A., Pawelec G., Guldberg P.
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_2148
ESTDAB; ESTDAB-057

Encyclopedic resources

Wikidata; Q54931191

Gene expression databases

GEO; GSM156014

Polymorphism and mutation databases

Cosmic; 972264
Cosmic; 1047648
Cosmic; 2163798
IARC_TP53; 26075
Progenetix; CVCL_2148

Entry history

Entry creation

04-Apr-2012

Last entry update

19-Dec-2024

Version number