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Cellosaurus LS174T-FX-R (CVCL_C4RY)

[Text version]
Cell line name LS174T-FX-R
Accession CVCL_C4RY
Resource Identification Initiative To cite this cell line use: LS174T-FX-R (RRID:CVCL_C4RY)
Comments Population: Caucasian.
Characteristics: Resistant to FOLFOXIRI, the combination of 5-FU, folinic acic, oxaliplatin and SN-38.
Selected for resistance to: ChEBI; CHEBI:46345; 5-fluorouracil (5-FU).
Selected for resistance to: ChEBI; CHEBI:15640; 5-formyltetrahydrofolic acid (Folinic acid; Leucovorin).
Selected for resistance to: ChEBI; CHEBI:31941; Oxaliplatin (Elotaxin; L-OHP).
Selected for resistance to: ChEBI; CHEBI:8988; SN-38 (7-ethyl-10-hydroxy-camptothecin).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1384 (LS174T)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line

PubMed=36230735; DOI=10.3390/cancers14194812
Ramzy G.M., Boschung L., Koessler T., Delucinge-Vivier C., Docquier M., McKee T.A., Rubbia-Brandt L., Nowak-Sliwinska P.
FOLFOXIRI resistance induction and characterization in human colorectal cancer cells.
Cancers (Basel) 14:4812.1-4812.17(2022)

Encyclopedic resources Wikidata; Q116049718
Entry history
Entry creation15-Dec-2022
Last entry update05-Oct-2023
Version number4