ID   LS174T-FX-R
AC   CVCL_C4RY
DR   Wikidata; Q116049718
RX   PubMed=36230735;
CC   Population: Caucasian.
CC   Characteristics: Resistant to FOLFOXIRI, the combination of 5-FU, folinic acic, oxaliplatin and SN-38.
CC   Selected for resistance to: ChEBI; CHEBI:46345; 5-fluorouracil (5-FU).
CC   Selected for resistance to: ChEBI; CHEBI:15640; 5-formyltetrahydrofolic acid (Folinic acid; Leucovorin).
CC   Selected for resistance to: ChEBI; CHEBI:31941; Oxaliplatin (Elotaxin; L-OHP).
CC   Selected for resistance to: ChEBI; CHEBI:8988; SN-38 (7-ethyl-10-hydroxy-camptothecin).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Phe (c.134C>T); ClinVar=VCV000017588; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
CC   Cell type: Epithelial cell of colon; CL=CL_0011108.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1384 ! LS174T
SX   Female
AG   58Y
CA   Cancer cell line
DT   Created: 15-12-22; Last updated: 05-10-23; Version: 4
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RX   PubMed=36230735; DOI=10.3390/cancers14194812;
RA   Ramzy G.M., Boschung L., Koessler T., Delucinge-Vivier C.,
RA   Docquier M., McKee T.A., Rubbia-Brandt L., Nowak-Sliwinska P.;
RT   "FOLFOXIRI resistance induction and characterization in human
RT   colorectal cancer cells.";
RL   Cancers (Basel) 14:4812.1-4812.17(2022).
//