Cellosaurus cell line CuFi-3 (CVCL

Cellosaurus CuFi-3 (CVCL_C458)

[Text version]

Cell line name

CuFi-3

Synonyms

CuFi3; Cystic Fibrosis, University of Iowa-3

Accession

CVCL_C458

Resource Identification Initiative

To cite this cell line use: CuFi-3 (RRID:CVCL_C458)

Comments

Karyotypic information: 48,XY,+5,+20 [10] (PubMed=12676769).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.

Sequence variations

Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Heterozygous (PubMed=12676769).
Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Arg553Ter (c.1657C>T); ClinVar=VCV000007122; Zygosity=Heterozygous (PubMed=12676769).

Disease

Cystic fibrosis (NCIt: C2975)
Cystic fibrosis (ORDO: Orphanet_586)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

15Y

Category

Transformed cell line

STR profile

Source(s): ATCC=CRL-4014

Markers:

Amelogenin	X,Y
CSF1PO	10,13
D5S818	11,12
D7S820	10,11
D13S317	11,12
D16S539	12,13
TH01	9,9.3
TPOX	10,11
vWA	16,19

Publications

PubMed=12676769; DOI=10.1152/ajplung.00355.2002
Zabner J., Karp P., Seiler M., Phillips S.L., Mitchell C.J., Saavedra M.T., Welsh M., Klingelhutz A.J.
Development of cystic fibrosis and noncystic fibrosis airway cell lines.
Am. J. Physiol. Lung Cell. Mol. Physiol. 284:L844-L854(2003)

PubMed=17191107; DOI=10.1007/s10238-006-0116-5
Gambardella S., Biancolella M., D'Apice M.R., Amati F., Sangiuolo F., Farcomeni A., Chillemi G., Bueno S., Desideri A., Novelli G.
Gene expression profile study in CFTR mutated bronchial cell lines.
Clin. Exp. Med. 6:157-165(2006)

Cross-references

Cell line collections (Providers)

ATCC; CRL-4014 - Discontinued
CancerTools; 154446

Biological sample resources

BioSample; SAMN03471723

Encyclopedic resources

Wikidata; Q54814856

Entry history

Entry creation

22-Oct-2012

Last entry update

10-Apr-2025

Version number