Cellosaurus cell line UKRV-Mel-20c (CVCL

Cellosaurus UKRV-Mel-20c (CVCL_C402)

[Text version]

Cell line name

UKRV-Mel-20c

Accession

CVCL_C402

Resource Identification Initiative

To cite this cell line use: UKRV-Mel-20c (RRID:CVCL_C402)

Sequence variations

Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Heterozygous (PubMed=26909863).
Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Heterozygous (PubMed=26909863).
Gene fusion; HGNC; HGNC:7413; MTAP + HGNC; HGNC:34341; CDKN2B-AS1; Name(s)=MTAP-ANRIL (PubMed=26909863).
Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Unspecified (PubMed=23348503).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).

Disease

Melanoma (NCIt: C3224)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Originate from same individual

CVCL_A721 ! UKRV-Mel-20a
CVCL_C401 ! UKRV-Mel-20b
CVCL_C403 ! UKRV-Mel-20e
CVCL_C404 ! UKRV-Mel-20f
CVCL_C405 ! UKRV-Mel-20h

Sex of cell

Male

Age at sampling

27Y

Category

Cancer cell line

STR profile

Source(s): ESTDAB=ESTDAB-234

Markers:

Amelogenin	X,Y
CSF1PO	13
D3S1358	16,17
D5S818	12,14
D7S820	10,12
D13S317	12
FGA	21,25
TH01	7,9
TPOX	8
vWA	16,19

Publications

PubMed=23348503; DOI=10.1126/science.1230062
Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A., Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R.
TERT promoter mutations in familial and sporadic melanoma.
Science 339:959-961(2013)

PubMed=26909863; DOI=10.18632/oncotarget.7503; PMCID=PMC4941330
Xie H.-P., Rachakonda P.S., Heidenreich B., Nagore E., Sucker A., Hemminki K., Schadendorf D., Kumar R.
Mapping of deletion breakpoints at the CDKN2A locus in melanoma: detection of MTAP-ANRIL fusion transcripts.
Oncotarget 7:16490-16504(2016)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_C402
ESTDAB; ESTDAB-234

Encyclopedic resources

Wikidata; Q54990611

Polymorphism and mutation databases

Cosmic; 1846711
Cosmic; 2686524

Entry history

Entry creation

22-Oct-2012

Last entry update

19-Dec-2024

Version number