Cellosaurus cell line UKRV-Mel-20a (CVCL

Cellosaurus UKRV-Mel-20a (CVCL_A721)

Cross-references
Cell line name	UKRV-Mel-20a
Accession	CVCL_A721
Resource Identification Initiative	To cite this cell line use: UKRV-Mel-20a (RRID:CVCL_A721)
Comments	Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072. Derived from site: Metastatic; Skin; UBERON=UBERON_0002097.
Sequence variations	Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=17311103; PubMed=23348503). Mutation; HGNC; HGNC:11730; TERT; Simple; c.242_243CC>TT (-138/-139CC>TT); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
Disease	Melanoma (NCIt: C3224)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_C401 ! UKRV-Mel-20b CVCL_C402 ! UKRV-Mel-20c CVCL_C403 ! UKRV-Mel-20e CVCL_C404 ! UKRV-Mel-20f CVCL_C405 ! UKRV-Mel-20h
Sex of cell	Male
Age at sampling	27Y
Category	Cancer cell line
Publications	PubMed=17311103; DOI=10.1371/journal.pone.0000236; PMCID=PMC1794595 Ugurel S., Thirumaran R.K., Bloethner S., Gast A., Sucker A., Mueller-Berghaus J., Rittgen W., Hemminki K., Becker J.C., Kumar R., Schadendorf D. B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis. PLoS ONE 2:E236-E236(2007) PubMed=23348503; DOI=10.1126/science.1230062 Horn S., Figl A., Rachakonda P.S., Fischer C., Sucker A., Gast A., Kadel S., Moll I., Nagore E., Hemminki K., Schadendorf D., Kumar R. TERT promoter mutations in familial and sporadic melanoma. Science 339:959-961(2013)
Cell line databases/resources	cancercelllines; CVCL_A721
Encyclopedic resources	Wikidata; Q54990608
Polymorphism and mutation databases	Cosmic; 1846710 Cosmic; 2686523
Entry history
Entry creation	06-Jun-2012
Last entry update	19-Dec-2024
Version number	18