Cellosaurus cell line AsPC-1 SPINK1 #10 (CVCL

Cellosaurus AsPC-1 SPINK1 #10 (CVCL_C3NE)

Cross-references
Cell line name	AsPC-1 SPINK1 #10
Accession	CVCL_C3NE
Resource Identification Initiative	To cite this cell line use: AsPC-1 SPINK1 #10 (RRID:CVCL_C3NE)
Comments	Population: Caucasian. Characteristics: Transduced with a lentiviral CMV-SPINK1-2A-eGFP construct. Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11244; SPINK1. Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP). Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR). Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations	Gene deletion; HGNC; HGNC:6844; MAP2K4; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Leu78Hisfs41 (c.233_234delTC) (p.His93Profs67, c.276_277delTC); ClinVar=VCV000977782; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Arg100Thr (c.299G>C); Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys135Alafs*35 (c.403delT); ClinVar=VCV001069265; Zygosity=Heterozygous (from parent cell line).
Disease	Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0152 (AsPC-1)
Sex of cell	Female
Age at sampling	62Y
Category	Cancer cell line
Publications	PubMed=26586397; DOI=10.1007/s13277-015-4405-z Zhang J., Wang D.-M., Hu N., Wang Q., Yu S., Wang J. The construction and proliferative effects of a lentiviral vector capable of stably overexpressing SPINK1 gene in human pancreatic cancer AsPC-1 cell line. Tumor Biol. 37:5847-5855(2016)
Cell line collections (Providers)	ABM; T3154
Encyclopedic resources	Wikidata; Q116048527
Entry history
Entry creation	15-Dec-2022
Last entry update	19-Dec-2024
Version number	5