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Cellosaurus AsPC-1 SPINK1 #10 (CVCL_C3NE)

[Text version]
Cell line name AsPC-1 SPINK1 #10
Accession CVCL_C3NE
Resource Identification Initiative To cite this cell line use: AsPC-1 SPINK1 #10 (RRID:CVCL_C3NE)
Comments Population: Caucasian.
Characteristics: Transduced with a lentiviral CMV-SPINK1-2A-eGFP construct.
Genetic integration: Method=Transduction; Gene=HGNC; 11244; SPINK1.
Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Gene deletion; HGNC; 6844; MAP2K4; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Leu78Hisfs*41 (c.233_234delTC) (p.His93Profs*67, c.276_277delTC); ClinVar=VCV000977782; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Arg100Thr (c.299G>C); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Cys135Alafs*35 (c.403delT); ClinVar=VCV001069265; Zygosity=Heterozygous (from parent cell line).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0152 (AsPC-1)
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line
Publications

PubMed=26586397; DOI=10.1007/s13277-015-4405-z
Zhang J., Wang D.-M., Hu N., Wang Q., Yu S., Wang J.
The construction and proliferative effects of a lentiviral vector capable of stably overexpressing SPINK1 gene in human pancreatic cancer AsPC-1 cell line.
Tumor Biol. 37:5847-5855(2016)

Cross-references
Cell line collections (Providers) ABM; T3154
Encyclopedic resources Wikidata; Q116048527
Entry history
Entry creation15-Dec-2022
Last entry update10-Sep-2024
Version number4