ID   AsPC-1 SPINK1 #10
AC   CVCL_C3NE
DR   ABM; T3154
DR   Wikidata; Q116048527
RX   PubMed=26586397;
CC   Population: Caucasian.
CC   Characteristics: Transduced with a lentiviral CMV-SPINK1-2A-eGFP construct.
CC   Sequence variation: Gene deletion; HGNC; 6844; MAP2K4; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Leu78Hisfs*41 (c.233_234delTC) (p.His93Profs*67, c.276_277delTC); ClinVar=VCV000977782; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Arg100Thr (c.299G>C); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Cys135Alafs*35 (c.403delT); ClinVar=VCV001069265; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 11244; SPINK1.
CC   Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
CC   Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0152 ! AsPC-1
SX   Female
AG   62Y
CA   Cancer cell line
DT   Created: 15-12-22; Last updated: 29-06-23; Version: 3
//
RX   PubMed=26586397; DOI=10.1007/s13277-015-4405-z;
RA   Zhang J., Wang D.-M., Hu N., Wang Q., Yu S., Wang J.;
RT   "The construction and proliferative effects of a lentiviral vector
RT   capable of stably overexpressing SPINK1 gene in human pancreatic
RT   cancer AsPC-1 cell line.";
RL   Tumor Biol. 37:5847-5855(2016).
//