Cellosaurus logo
expasy logo

Cellosaurus GIST-T1/IM-R (CVCL_C3M2)

[Text version]
Cell line name GIST-T1/IM-R
Accession CVCL_C3M2
Resource Identification Initiative To cite this cell line use: GIST-T1/IM-R (RRID:CVCL_C3M2)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI_45783; Imatinib (Gleevec; STI571).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Cell type: Interstitial cell of Cajal; CL=CL_0002088.
Sequence variations
  • Mutation; HGNC; HGNC:6342; KIT; Simple; p.Val560_Tyr578del (c.1679_1735del); Zygosity=Heterozygous (PubMed=34738628).
  • Mutation; HGNC; HGNC:8803; PDGFRA; Simple; p.Pro567Pro (c.1701A>G); ClinVar=VCV000259949; Zygosity=Unspecified (PubMed=34738628).
Disease Gastrointestinal stromal tumor (NCIt: C3868)
Gastrointestinal stromal tumor (ORDO: Orphanet_44890)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4976 (GIST-T1)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line
Publications

PubMed=34738628; DOI=10.3892/or.2021.8218; PMCID=PMC8600406
Shima T., Taniguchi K., Tokumaru Y., Inomata Y., Arima J., Lee S.-W., Takabe K., Yoshida K., Uchiyama K.
Glucose transporter-1 inhibition overcomes imatinib resistance in gastrointestinal stromal tumor cells.
Oncol. Rep. 47:7.1-7.13(2022)

Cross-references
Encyclopedic resources Wikidata; Q116049078
Entry history
Entry creation15-Dec-2022
Last entry update19-Dec-2024
Version number5