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Cellosaurus COLO 205_6244R (CVCL_C3GG)

[Text version]
Cell line name COLO 205_6244R
Synonyms C6244-R; C6244-R1
Accession CVCL_C3GG
Resource Identification Initiative To cite this cell line use: COLO 205_6244R (RRID:CVCL_C3GG)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_90227; Selumetinib (AZD6244).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Asn287Ser (c.860A>G); ClinVar=VCV000133954; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr103fs*37 (c.308_321delTGTGTAACAGTTCC); Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0218 (COLO 205)
Sex of cell Male
Age at sampling 70Y
Category Cancer cell line
Publications

PubMed=21447798; DOI=10.1126/scisignal.2001752
Little A.S., Balmanno K., Sale M.J., Newman S., Dry J.R., Hampson M., Edwards P.A.W., Smith P.D., Cook S.J.
Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells.
Sci. Signal. 4:Ra17.1-Ra17.15(2011)

PubMed=31048689; DOI=10.1038/s41467-019-09438-w; PMCID=PMC6497655
Sale M.J., Balmanno K., Saxena J., Ozono E., Wojdyla K., McIntyre R.E., Gilley R., Woroniuk A., Howarth K.D., Hughes G., Dry J.R., Arends M.J., Caro P., Oxley D., Ashton S., Adams D.J., Saez-Rodriguez J., Smith P.D., Cook S.J.
MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAF(V600E) amplification whereas KRAS(G13D) amplification promotes EMT-chemoresistance.
Nat. Commun. 10:2030.1-2030.22(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C3GG
Encyclopedic resources Wikidata; Q114310997
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number6