ID   COLO 205_6244R
AC   CVCL_C3GG
SY   C6244-R; C6244-R1
DR   cancercelllines; CVCL_C3GG
DR   Wikidata; Q114310997
RX   PubMed=21447798;
RX   PubMed=31048689;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:90227; Selumetinib (AZD6244).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Asn287Ser (c.860A>G); ClinVar=VCV000133954; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr103fs*37 (c.308_321delTGTGTAACAGTTCC); Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0218 ! COLO 205
SX   Male
AG   70Y
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 05-10-23; Version: 5
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RX   PubMed=21447798; DOI=10.1126/scisignal.2001752;
RA   Little A.S., Balmanno K., Sale M.J., Newman S., Dry J.R., Hampson M.,
RA   Edwards P.A.W., Smith P.D., Cook S.J.;
RT   "Amplification of the driving oncogene, KRAS or BRAF, underpins
RT   acquired resistance to MEK1/2 inhibitors in colorectal cancer cells.";
RL   Sci. Signal. 4:Ra17.1-Ra17.15(2011).
//
RX   PubMed=31048689; DOI=10.1038/s41467-019-09438-w;
RA   Sale M.J., Balmanno K., Saxena J., Ozono E., Wojdyla K.,
RA   McIntyre R.E., Gilley R., Woroniuk A., Howarth K.D., Hughes G.,
RA   Dry J.R., Arends M.J., Caro P., Oxley D., Ashton S., Adams D.J.,
RA   Saez-Rodriguez J., Smith P.D., Cook S.J.;
RT   "MEK1/2 inhibitor withdrawal reverses acquired resistance driven by
RT   BRAF(V600E) amplification whereas KRAS(G13D) amplification promotes
RT   EMT-chemoresistance.";
RL   Nat. Commun. 10:2030.1-2030.22(2019).
//