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Cellosaurus A549 EGFR Biosensor (CVCL_C3ET)

[Text version]
Cell line name A549 EGFR Biosensor
Synonyms A549 EGFR SH2 Biosensor
Accession CVCL_C3ET
Resource Identification Initiative To cite this cell line use: A549 EGFR Biosensor (RRID:CVCL_C3ET)
Comments Population: Caucasian.
Characteristics: Within minutes after stimulation of the cell line with EGF, the biosensor shows robust redistribution towards the cell membrane and subsequent internalization through endocytosis (Sigma-Aldrich=CLL1097).
Characteristics: Transduced with a TagGFP2-SH2-SH2 construct (Sigma-Aldrich=CLL1097).
Genetic integration: Method=Transduction; Gene=FPbase; GJETS; TagGFP2 (Note=Green fluorescent protein derived from Aequorea macrodactyla GFP).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Sigma-Aldrich; CLL1097
Cell line databases/resources cancercelllines; CVCL_C3ET
Encyclopedic resources Wikidata; Q114310513
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number7