ID   A549 EGFR Biosensor
AC   CVCL_C3ET
SY   A549 EGFR SH2 Biosensor
DR   cancercelllines; CVCL_C3ET
DR   Wikidata; Q114310513
WW   https://www.sigmaaldrich.com/catalog/product/sigma/cll1097
CC   Population: Caucasian.
CC   Characteristics: Within minutes after stimulation of the cell line with EGF, the biosensor shows robust redistribution towards the cell membrane and subsequent internalization through endocytosis (Sigma-Aldrich).
CC   Characteristics: Transduced with a TagGFP2-SH2-SH2 construct.
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; Q8WTC6; Aequorea macrodactyla GFP (with p.Lys3Gly, p.Thr9Ala, p.Ser65Cys, p.Phe99Gln, p.Met128Lys, p.Asn144Ser, p.Met153Arg, p.Lys162Glu, p.Val163Ala, p.Ile167Thr, p.Ala206Lys, p.Thr214Ala, p.Phe220Leu, p.Phe223Ser, p.Gly228Cys and Lys238Arg = TagGFP2).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0023 ! A-549
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 05-10-23; Version: 5
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