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Cellosaurus ALL-VG TKI-resistant (CVCL_C1MF)

[Text version]
Cell line name ALL-VG TKI-resistant
Accession CVCL_C1MF
Resource Identification Initiative To cite this cell line use: ALL-VG TKI-resistant (RRID:CVCL_C1MF)
Comments Selected for resistance to: ChEBI; CHEBI_45783; Imatinib (Gleevec; STI571).
Omics: Deep exome analysis.
Omics: Proteome analysis by 2D-DE/MS.
Omics: SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; HGNC:1785; CDKN1B; Zygosity=Unspecified (from parent cell line).
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Unspecified (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Unspecified (from parent cell line).
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:3495; ETV6; Name(s)=ETV6-ABL1 (PubMed=28650474).
  • Mutation; HGNC; HGNC:4396; GNB1; Simple; p.Lys89Met (c.266A>T); ClinVar=VCV001360749; Zygosity=Heterozygous; Note=Involved in imatinib resistance (PubMed=28650474).
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C1ME (ALL-VG)
Sex of cell Male
Age at sampling 30Y
Category Cancer cell line
Publications

PubMed=28650474; DOI=10.1038/onc.2017.210; PMCID=PMC5666322
Zimmermannova O., Doktorova E., Stuchly J., Kanderova V., Kuzilkova D., Strnad H., Starkova J., Alberich-Jorda M., Falkenburg J.H.F., Trka J., Petrak J., Zuna J., Zaliova M.
An activating mutation of GNB1 is associated with resistance to tyrosine kinase inhibitors in ETV6-ABL1-positive leukemia.
Oncogene 36:5985-5994(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C1MF
Encyclopedic resources Wikidata; Q114310623
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number6