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Cellosaurus CI-hAELVi (CVCL_C1M0)

[Text version]
Cell line name CI-hAELVi
Synonyms hAELVi.A; human Alveolar Epithelial Lentivirus immortalized clone A
Accession CVCL_C1M0
Resource Identification Initiative To cite this cell line use: CI-hAELVi (RRID:CVCL_C1M0)
Comments Characteristics: Suitable to model the air-blood barrier of the peripheral lung. Forms tight intercellular junctions, with high trans-epithelial electrical resistance (PubMed=26985677).
Characteristics: Transduced with a lentiviral library consisting of 33 genes, some of which are retained in the immortalized cell line (CI-SCREEN) (PubMed=26985677).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5361; ID2.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5362; ID3.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:7553; MYC.
Genetic integration: Method=Transduction; Gene=MGI; MGI:88138; Bcl2.
Genetic integration: Method=Transduction; Gene=MGI; MGI:1919200; Nanog.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=Hepatitis C virus core protein.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Lung, alveolus; UBERON=UBERON_0002299.
Cell type: Type 1 pneumocyte; CL=CL_0002062.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E6BF (CI-huArlo)
Originate from same individual CVCL_C1M1 ! hAELVi.B
Sex of cell Male
Age at sampling Age unspecified
Category Transformed cell line
STR profile Source(s): InSCREENeX=INS-CI-1015

Markers:
AmelogeninX,Y
CSF1PO10,13
D2S133817
D3S135815,17
D5S81811
D7S82011
D8S117914,15
D13S31710,12
D16S53911
D18S5115,16
D19S43313,13.2
D21S1130.2,33.2
FGA23
TH019
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Web pages Provider; InSCREENeX; INS-CI-1015; https://www.inscreenex.de/product/ci-haelvi/
Publications

PubMed=26985677; DOI=10.14573/altex.1511131
Kuehn A., Kletting S., de Souza Carvalho-Wodarz C., Repnik U., Griffiths G.W., Fischer U., Meese E.U., Huwer H., Wirth D., May T., Schneider-Daum N., Lehr C.-M.
Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier.
ALTEX 33:251-260(2016)

PubMed=36748276; DOI=10.1002/advs.202207301; PMCID=PMC10015904
Carius P., Jungmann A., Bechtel M., Grissmer A., Boese A., Gasparoni G., Salhab A., Seipelt R., Urbschat K., Richter C., Meier C., Bojkova D., Cinatl J. Jr., Walter J., Schneider-Daum N., Lehr C.-M.
A monoclonal human alveolar epithelial cell line ('Arlo') with pronounced barrier function for studying drug permeability and viral infections.
Adv. Sci. (Weinh.) 10:2207301.1-2207301.23(2023)

Cross-references
Encyclopedic resources Wikidata; Q114311559
Entry history
Entry creation22-Sep-2022
Last entry update10-Apr-2025
Version number7