Cellosaurus logo
expasy logo

Cellosaurus BEL-A 4x KO (CVCL_C0XH)

[Text version]
Cell line name BEL-A 4x KO
Accession CVCL_C0XH
Resource Identification Initiative To cite this cell line use: BEL-A 4x KO (RRID:CVCL_C0XH)
Comments Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:4035; ACKR1.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:4012; FUT1.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:4703; GYPB.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:6308; KEL.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Cell type: Mononuclear cell of bone marrow; CL=CL_0010004.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C0XD (BEL-A GPB KO)
Children:
CVCL_C0XI (BEL-A 5x KO)
Sex of cell Sex unspecified
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=29700043; DOI=10.15252/emmm.201708454; PMCID=PMC5991592
Hawksworth J.S., Satchwell T.J., Meinders M., Daniels D.E., Regan F., Thornton N.M., Wilson M.C., Dobbe J.G.G., Streekstra G.J., Trakarnsanga K., Heesom K.J., Anstee D.J., Frayne J., Toye A.M.
Enhancement of red blood cell transfusion compatibility using CRISPR-mediated erythroblast gene editing.
EMBO Mol. Med. 10:e8454.1-e8454.11(2018)

CLPUB00710
Hawksworth J.S.
CRISPR-Cas9 gene editing in an immortalized erythroid cell line for production of engineered red blood cells.
Thesis PhD (2019); University of Bristol; Bristol; United Kingdom

Cross-references
Encyclopedic resources Wikidata; Q114310728
Entry history
Entry creation22-Sep-2022
Last entry update10-Apr-2025
Version number8