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Cellosaurus SK4-Rf (CVCL_C0X0)

[Text version]
Cell line name SK4-Rf
Accession CVCL_C0X0
Resource Identification Initiative To cite this cell line use: SK4-Rf (RRID:CVCL_C0X0)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_46345; 5-fluorouracil (5-FU).
Derived from site: In situ; Esophagus, distal; UBERON=UBERON_0013473.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln100Ter (c.298C>T); ClinVar=VCV000634707; Zygosity=Homozygous (from parent cell line).
Disease Esophageal adenocarcinoma (NCIt: C4025)
Adenocarcinoma of the esophagus (ORDO: Orphanet_99976)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2195 (SK-GT-4)
Sex of cell Male
Age at sampling 89Y
Category Cancer cell line
Cross-references
Cell line databases/resources cancercelllines; CVCL_C0X0
Encyclopedic resources Wikidata; Q114313030
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number6