Cellosaurus cell line LNCaP-PDR2 (CVCL

Cellosaurus LNCaP-PDR2 (CVCL_C0RS)

Cross-references
Cell line name	LNCaP-PDR2
Synonyms	LNCaP PDR2; LN-PDR2
Accession	CVCL_C0RS
Resource Identification Initiative	To cite this cell line use: LNCaP-PDR2 (RRID:CVCL_C0RS)
Comments	Population: Caucasian. Selected for resistance to: ChEBI; CHEBI:85993; Palbociclib (Ibrance). Omics: Deep quantitative phosphoproteome analysis. Omics: Transcriptome analysis by RNAseq. Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations	Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line). Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease	Prostate carcinoma (NCIt: C4863)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0395 (LNCaP)
Sex of cell	Male
Age at sampling	50Y
Category	Cancer cell line
Publications	PubMed=29739788; DOI=10.1158/1078-0432.CCR-18-0410; PMCID=PMC6125187 de Leeuw R., McNair C., Schiewer M.J., Poudel-Neupane N., Brand L.J., Augello M.A., Li Z., Cheng L.C., Yoshida A., Courtney S.M., Hazard E.S., Hardiman G., Hussain M.H., Diehl J.A., Drake J.M., Kelly W.K., Knudsen K.E. MAPK reliance via acquired CDK4/6 inhibitor resistance in cancer. Clin. Cancer Res. 24:4201-4214(2018)
Cell line databases/resources	cancercelllines; CVCL_C0RS
Encyclopedic resources	Wikidata; Q112930020
Gene expression databases	GEO; GSM2650011 GEO; GSM2650012 GEO; GSM2650013 GEO; GSM2650014 GEO; GSM2650015 GEO; GSM2650016
Proteomic databases	PRIDE; PXD006561
Entry history
Entry creation	23-Jun-2022
Last entry update	05-Oct-2023
Version number	5