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Cellosaurus LNCaP-PDR2 (CVCL_C0RS)

[Text version]
Cell line name LNCaP-PDR2
Synonyms LNCaP PDR2; LN-PDR2
Accession CVCL_C0RS
Resource Identification Initiative To cite this cell line use: LNCaP-PDR2 (RRID:CVCL_C0RS)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_85993; Palbociclib (Ibrance).
Omics: Deep quantitative phosphoproteome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0395 (LNCaP)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=29739788; DOI=10.1158/1078-0432.CCR-18-0410; PMCID=PMC6125187
de Leeuw R., McNair C., Schiewer M.J., Poudel-Neupane N., Brand L.J., Augello M.A., Li Z., Cheng L.C., Yoshida A., Courtney S.M., Hazard E.S., Hardiman G., Hussain M.H., Diehl J.A., Drake J.M., Kelly W.K., Knudsen K.E.
MAPK reliance via acquired CDK4/6 inhibitor resistance in cancer.
Clin. Cancer Res. 24:4201-4214(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0RS
Encyclopedic resources Wikidata; Q112930020
Gene expression databases GEO; GSM2650011
GEO; GSM2650012
GEO; GSM2650013
GEO; GSM2650014
GEO; GSM2650015
GEO; GSM2650016
Proteomic databases PRIDE; PXD006561
Entry history
Entry creation23-Jun-2022
Last entry update19-Dec-2024
Version number6