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Cellosaurus HT1080 EWSR1-FLI1-EGFP (CVCL_C0RG)

[Text version]
Cell line name HT1080 EWSR1-FLI1-EGFP
Synonyms HT1080_EWSR1-FLI1-EGFP
Accession CVCL_C0RG
Resource Identification Initiative To cite this cell line use: HT1080 EWSR1-FLI1-EGFP (RRID:CVCL_C0RG)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 3508; EWSR1 (Note=EWSR1-FLI1 fusion).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 3749; FLI1 (Note=EWSR1-FLI1 fusion).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0317 (HT-1080)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Publications

PubMed=30962207; DOI=10.15252/embr.201845766; PMCID=PMC6500973
Linden M., Thomsen C., Grundevik P., Jonasson E., Andersson D., Runnberg R., Dolatabadi S., Vannas C., Santamaria M.L., Fagman H., Stahlberg A., Aman P.
FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex.
EMBO Rep. 20:e45766.1-e45766.15(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0RG
Encyclopedic resources Wikidata; Q112929756
Gene expression databases GEO; GSM3585522
GEO; GSM3585523
GEO; GSM3585524
GEO; GSM3585525
Entry history
Entry creation23-Jun-2022
Last entry update10-Sep-2024
Version number7