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Cellosaurus U2OS GFP-PEAK3 (CVCL_C0QT)

[Text version]
Cell line name U2OS GFP-PEAK3
Accession CVCL_C0QT
Resource Identification Initiative To cite this cell line use: U2OS GFP-PEAK3 (RRID:CVCL_C0QT)
Comments Population: Caucasian.
Characteristics: Transfected with a pBABE-GFP-PEAK3 construct that contains a GFP-PEAK3 fusion (PubMed=34944965).
Genetic integration: Method=Transfection; Gene=HGNC; 24793; PEAK3.
Genetic integration: Method=Transfection; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; 9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=34944965; DOI=10.3390/cancers13246344; PMCID=PMC8699254
Ounoughene Y., Fourgous E., Boublik Y., Saland E., Guiraud N., Recher C., Urbach S., Fort P., Sarry J.-E., Fesquet D., Roche S.
SHED-dependent oncogenic signaling of the PEAK3 pseudo-kinase.
Cancers (Basel) 13:6344.1-6344.18(2021)

Cross-references
Encyclopedic resources Wikidata; Q112930494
Entry history
Entry creation23-Jun-2022
Last entry update10-Sep-2024
Version number6