Cellosaurus PC-DR-LUC (CVCL_C0Q0)
| Cell line name | PC-DR-LUC |
|---|---|
| Accession | CVCL_C0Q0 |
| Resource Identification Initiative | To cite this cell line use: PC-DR-LUC (RRID:CVCL_C0Q0) |
| Comments | Biotechnology: Used in an assay that can be used to identify compounds that have thyromimetic or TH-antagonistic effects, and that could be useful for detecting thyroid-disrupting chemicals in environmental samples (PubMed=17532181). Characteristics: Expression of luciferase is under the control of a promoter containing two thyroid hormone response elements (TREs) separated by four nucleotides (DR4) followed by a SV40 promoter (PubMed=17532181). Genetic integration: Method=Transfection/transduction; Gene=CGNC; 155; THRA. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Derived from site: In situ; Adrenal gland; UBERON=UBERON_0002369. |
| Disease | Rat adrenal gland pheochromocytoma (NCIt: C121568) |
| Species of origin | Rattus norvegicus (Rat)
(NCBI Taxonomy: 10116)
Breed/subspecies: NEDH; RS=RS:0000603. |
| Hierarchy | Parent: CVCL_C0PZ (PC12 cA4) |
| Sex of cell | Male |
| Age at sampling | Age unspecified |
| Category | Cancer cell line |
| Publications | PubMed=17532181; DOI=10.1016/j.tiv.2007.03.020 |
| Cross-references | |
| Encyclopedic resources | Wikidata; Q112930254 |
| Entry history | |
| Entry creation | 23-Jun-2022 |
| Last entry update | 10-Sep-2024 |
| Version number | 7 |