Cellosaurus cell line CuFi-8 (CVCL

Cellosaurus CuFi-8 (CVCL_C0GK)

Cross-references
Cell line name	CuFi-8
Synonyms	Cystic Fibrosis, University of Iowa-8
Accession	CVCL_C0GK
Resource Identification Initiative	To cite this cell line use: CuFi-8 (RRID:CVCL_C0GK)
Comments	Virology: Supports productive infection by human bocavirus 1 (HBoV1) (PubMed=22956907). Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6. Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7. Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16). Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031. Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Sequence variations	Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=32337159).
Disease	Cystic fibrosis (NCIt: C2975) Cystic fibrosis (ORDO: Orphanet_586)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Age at sampling	24Y
Category	Transformed cell line
Publications	PubMed=22956907; DOI=10.1371/journal.ppat.1002899; PMCID=PMC3431310 Huang Q.-F., Deng X.-F., Yan Z.-Y., Cheng F., Luo Y., Shen W.-R., Lei-Butters D.C.M., Chen A.Y., Li Y., Tang L., Soderlund-Venermo M., Engelhardt J.F., Qiu J.-M. Establishment of a reverse genetics system for studying human bocavirus in human airway epithelia. PLoS Pathog. 8:e1002899.1-e1002899.14(2012) PubMed=24825015; DOI=10.1128/mBio.01186-14; PMCID=PMC4030487 Schildgen V., Mai S., Khalfaoui S., Lusebrink J., Pieper M., Tillmann R.L., Brockmann M., Schildgen O. Pneumocystis jirovecii can be productively cultured in differentiated CuFi-8 airway cells. mBio 5:e01186.14.1-e01186.14.10(2014) PubMed=32337159; DOI=10.1016/j.ehpc.2016.07.001; PMCID=PMC7172079 Dieninghoff D., Karagiannidis C., Strassmann S., Pieper M., Dammaschek S., Zabner J., Klingelhutz A.J., Windisch W., Brockmann M., Schildgen O., Schildgen V. Fatal HBoV-1 infection in adult female cystic fibrosis patient. Hum. Pathol. (N.Y.) 7:51-52(2017)
Cell line collections (Providers)	CancerTools; 154454 Ximbio; 154454
Encyclopedic resources	Wikidata; Q112929438
Entry history
Entry creation	23-Jun-2022
Last entry update	10-Apr-2025
Version number	9