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Cellosaurus CuFi-8 (CVCL_C0GK)

[Text version]
Cell line name CuFi-8
Synonyms Cystic Fibrosis, University of Iowa-8
Accession CVCL_C0GK
Resource Identification Initiative To cite this cell line use: CuFi-8 (RRID:CVCL_C0GK)
Comments Virology: Supports productive infection by human bocavirus 1 (HBoV1) (PubMed=22956907).
Transfected with: HGNC; 11730; TERT.
Transfected with: UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Transfected with: UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Sequence variations
  • Mutation; HGNC; 1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=32337159).
Disease Cystic fibrosis (NCIt: C2975)
Cystic fibrosis (ORDO: Orphanet_586)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 24Y
Category Transformed cell line
Publications

PubMed=22956907; DOI=10.1371/journal.ppat.1002899
Huang Q.-F., Deng X.-F., Yan Z.-Y., Cheng F., Luo Y., Shen W.-R., Lei-Butters D.C.M., Chen A.Y., Li Y., Tang L., Soderlund-Venermo M., Engelhardt J.F., Qiu J.-M.
Establishment of a reverse genetics system for studying human bocavirus in human airway epithelia.
PLoS Pathog. 8:E1002899-E1002899(2012)

PubMed=24825015; DOI=10.1128/mBio.01186-14
Schildgen V., Mai S., Khalfaoui S., Lusebrink J., Pieper M., Tillmann R.L., Brockmann M., Schildgen O.
Pneumocystis jirovecii can be productively cultured in differentiated CuFi-8 airway cells.
mBio 5:e01186.14.1-e01186.14.10(2014)

PubMed=32337159; DOI=10.1016/j.ehpc.2016.07.001
Dieninghoff D., Karagiannidis C., Strassmann S., Pieper M., Dammaschek S., Zabner J., Klingelhutz A.J., Windisch W., Brockmann M., Schildgen O., Schildgen V.
Fatal HBoV-1 infection in adult female cystic fibrosis patient.
Hum. Pathol. (N.Y.) 7:51-52(2017)

Cross-references
Cell line collections (Providers) Ximbio; 154454
Encyclopedic resources Wikidata; Q112929438
Entry history
Entry creation23-Jun-2022
Last entry update05-Oct-2023
Version number6