ID   CuFi-8
AC   CVCL_C0GK
SY   Cystic Fibrosis, University of Iowa-8
DR   Wikidata; Q112929438
DR   Ximbio; 154454
RX   PubMed=22956907;
RX   PubMed=24825015;
RX   PubMed=32337159;
CC   Virology: Supports productive infection by human bocavirus 1 (HBoV1) (PubMed=22956907).
CC   Sequence variation: Mutation; HGNC; 1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=32337159).
CC   Genetic integration: Method=Transduction; Gene=HGNC; 11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
CC   Cell type: Epithelial cell of bronchus; CL=CL_0002328.
DI   NCIt; C2975; Cystic fibrosis
DI   ORDO; Orphanet_586; Cystic fibrosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   24Y
CA   Transformed cell line
DT   Created: 23-06-22; Last updated: 10-09-24; Version: 7
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RX   PubMed=22956907; DOI=10.1371/journal.ppat.1002899; PMCID=PMC3431310;
RA   Huang Q.-F., Deng X.-F., Yan Z.-Y., Cheng F., Luo Y., Shen W.-R.,
RA   Lei-Butters D.C.M., Chen A.Y., Li Y., Tang L., Soderlund-Venermo M.,
RA   Engelhardt J.F., Qiu J.-M.;
RT   "Establishment of a reverse genetics system for studying human
RT   bocavirus in human airway epithelia.";
RL   PLoS Pathog. 8:E1002899-E1002899(2012).
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RX   PubMed=24825015; DOI=10.1128/mBio.01186-14; PMCID=PMC4030487;
RA   Schildgen V., Mai S., Khalfaoui S., Lusebrink J., Pieper M.,
RA   Tillmann R.L., Brockmann M., Schildgen O.;
RT   "Pneumocystis jirovecii can be productively cultured in differentiated
RT   CuFi-8 airway cells.";
RL   mBio 5:e01186.14.1-e01186.14.10(2014).
//
RX   PubMed=32337159; DOI=10.1016/j.ehpc.2016.07.001; PMCID=PMC7172079;
RA   Dieninghoff D., Karagiannidis C., Strassmann S., Pieper M.,
RA   Dammaschek S., Zabner J., Klingelhutz A.J., Windisch W., Brockmann M.,
RA   Schildgen O., Schildgen V.;
RT   "Fatal HBoV-1 infection in adult female cystic fibrosis patient.";
RL   Hum. Pathol. (N.Y.) 7:51-52(2017).
//