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Cellosaurus e-hMEC-1 (CVCL_B7U6)

[Text version]
Cell line name e-hMEC-1
Accession CVCL_B7U6
Resource Identification Initiative To cite this cell line use: e-hMEC-1 (RRID:CVCL_B7U6)
Comments Characteristics: Transduced with a lentiviral library consisting of 33 genes, some of which are retained in the immortalized cell line (CI-SCREEN) (PubMed=29520052).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3527; EZH2.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3796; FOS.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:4317; GLI1.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5109; HOXA9.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5360; ID1.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5361; ID2.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5362; ID3.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:7553; MYC.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11195; SOX2.
Genetic integration: Method=Transduction; Gene=MGI; MGI:1919200; Nanog.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Skin, microvascular endothelium; UBERON=UBERON_0002097+UBERON_0008339.
Cell type: Microvascular endothelial cell; CL=CL_2000008.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_B7U7 ! e-hMEC-2
CVCL_B7U8 ! e-hMEC-3
Category Transformed cell line
Publications

PubMed=29520052; DOI=10.1038/s41467-018-03408-4; PMCID=PMC5843645
Lipps C., Klein F., Wahlicht T., Seiffert V., Butueva M., Zauers J., Truschel T., Luckner M., Koster M., MacLeod R.A.F., Pezoldt J., Huhn J., Yuan Q.-G., Muller P.P., Kempf H., Zweigerdt R., Dittrich-Breiholz O., Pufe T., Beckmann R., Drescher W., Riancho J.A., Sanudo C., Korff T., Opalka B., Rebmann V., Gothert J.R., Alves P.M., Ott M., Schucht R., Hauser H., Wirth D., May T.
Expansion of functional personalized cells with specific transgene combinations.
Nat. Commun. 9:994.1-994.12(2018)

Cross-references
Encyclopedic resources Wikidata; Q112929481
Entry history
Entry creation23-Jun-2022
Last entry update10-Apr-2025
Version number7