ID   e-hMEC-1
AC   CVCL_B7U6
DR   Wikidata; Q112929481
RX   PubMed=29520052;
CC   Characteristics: Transduced with a lentiviral library consisting of 33 genes, some of which are retained in the immortalized cell line (CI-SCREEN) (PubMed=29520052).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3527; EZH2.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3796; FOS.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:4317; GLI1.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5109; HOXA9.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5360; ID1.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5361; ID2.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5362; ID3.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:7553; MYC.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11195; SOX2.
CC   Genetic integration: Method=Transduction; Gene=MGI; MGI:1919200; Nanog.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Skin, microvascular endothelium; UBERON=UBERON_0002097+UBERON_0008339.
CC   Cell type: Microvascular endothelial cell; CL=CL_2000008.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_B7U7 ! e-hMEC-2
OI   CVCL_B7U8 ! e-hMEC-3
CA   Transformed cell line
DT   Created: 23-06-22; Last updated: 10-04-25; Version: 7
//
RX   PubMed=29520052; DOI=10.1038/s41467-018-03408-4; PMCID=PMC5843645;
RA   Lipps C., Klein F., Wahlicht T., Seiffert V., Butueva M., Zauers J.,
RA   Truschel T., Luckner M., Koster M., MacLeod R.A.F., Pezoldt J., Huhn J.,
RA   Yuan Q.-G., Muller P.P., Kempf H., Zweigerdt R., Dittrich-Breiholz O.,
RA   Pufe T., Beckmann R., Drescher W., Riancho J.A., Sanudo C., Korff T.,
RA   Opalka B., Rebmann V., Gothert J.R., Alves P.M., Ott M., Schucht R.,
RA   Hauser H., Wirth D., May T.;
RT   "Expansion of functional personalized cells with specific transgene
RT   combinations.";
RL   Nat. Commun. 9:994.1-994.12(2018).
//