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Cellosaurus MCF7/TROP2-KO (CVCL_B7JP)

[Text version]
Cell line name MCF7/TROP2-KO
Synonyms BINDS-29
Accession CVCL_B7JP
Resource Identification Initiative To cite this cell line use: MCF7/TROP2-KO (RRID:CVCL_B7JP)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; 11530; TACSTD2.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=33300065; DOI=10.3892/mmr.2020.11731; PMCID=PMC7723163
Sayama Y., Kaneko M.K., Kato Y.
Development and characterization of TrMab-6, a novel anti-TROP2 monoclonal antibody for antigen detection in breast cancer.
Mol. Med. Rep. 23:92.1-92.9(2021)

PubMed=33490649; DOI=10.1016/j.bbrep.2020.100902; PMCID=PMC7806523
Sayama Y., Kaneko M.K., Takei J., Hosono H., Sano M., Asano T., Kato Y.
Establishment of a novel anti-TROP2 monoclonal antibody TrMab-29 for immunohistochemical analysis.
Biochem. Biophys. Rep. 25:100902.1-100902.6(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7JP
Encyclopedic resources Wikidata; Q112930092
Entry history
Entry creation23-Jun-2022
Last entry update05-Oct-2023
Version number5