ID   MCF7/TROP2-KO
AC   CVCL_B7JP
SY   BINDS-29
DR   cancercelllines; CVCL_B7JP
DR   Wikidata; Q112930092
RX   PubMed=33300065;
RX   PubMed=33490649;
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; 11530; TACSTD2.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 23-06-22; Last updated: 05-10-23; Version: 5
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RX   PubMed=33300065; DOI=10.3892/mmr.2020.11731; PMCID=PMC7723163;
RA   Sayama Y., Kaneko M.K., Kato Y.;
RT   "Development and characterization of TrMab-6, a novel anti-TROP2
RT   monoclonal antibody for antigen detection in breast cancer.";
RL   Mol. Med. Rep. 23:92.1-92.9(2021).
//
RX   PubMed=33490649; DOI=10.1016/j.bbrep.2020.100902; PMCID=PMC7806523;
RA   Sayama Y., Kaneko M.K., Takei J., Hosono H., Sano M., Asano T.,
RA   Kato Y.;
RT   "Establishment of a novel anti-TROP2 monoclonal antibody TrMab-29 for
RT   immunohistochemical analysis.";
RL   Biochem. Biophys. Rep. 25:100902.1-100902.6(2021).
//