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Cellosaurus Mel Z (CVCL_B6KE)

[Text version]
Cell line name Mel Z
Synonyms mel Z
Accession CVCL_B6KE
Resource Identification Initiative To cite this cell line use: Mel Z (RRID:CVCL_B6KE)
Comments Group: Patented cell line.
Registration: Non-internationally recognized Depositary Authority, Russian Cell Culture Collection (RCCC); 711D.
Derived from site: Metastatic; Interscapular region, hypodermis; UBERON=UBERON_8480066+UBERON_0002072.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (CelloPub=CLPUB00680; PubMed=28881731; PubMed=30551515).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 55Y
Category Cancer cell line
Publications

PubMed=16107020
Mikhailova I.N., Lukashina M.I., Baryshnikov A.Y., Morozova L.F., Burova O.S., Palkina T.N., Kozlov A.M., Golubeva V.A., Cheremushkin E.A., Doroshenko M.B., Demidov L.V., Kiselev S.L., Larin S.S., Georgiev G.P.
Melanoma cell lines as the basis for antitumor vaccine preparation.
Vestn. Ross. Akad. Med. Nauk 2005:37-40(2005)

Patent=RU2390556
Mikhailova I.N., Baryshnikov A.Y., Demidov L.V., Kiselev S.L., Burova O.S., Morozova L.F., Vjacheslavovich S.I.
Human melanoma cell line mel Z used for making anti-tumour vaccines.
Patent number RU2390556, 27-May-2010

CLPUB00680
Mikhailova I.N., Baryshnikov A.Y., Morozova L.F., Burova O.S., Shubina I.Z., Kovalevsky D.A., Voronina E.S., Treshalina H.M., Lushnikova A.A., Tsyganova I.V., Mazurenko N.N.
Human skin melanoma cell lines collection.
(In) Management of malignant melanoma; pp.1-6; SM Group; Dover (2016)

PubMed=28881731; DOI=10.18632/oncotarget.17014
Emelyanova M., Ghukasyan L., Abramov I., Ryabaya O., Stepanova E.V., Kudryavtseva A., Sadritdinova A., Dzhumakova C., Belysheva T., Surzhikov S., Lyubchenko L., Zasedatelev A., Nasedkina T.
Detection of BRAF, NRAS, KIT, GNAQ, GNA11 and MAP2K1/2 mutations in Russian melanoma patients using LNA PCR clamp and biochip analysis.
Oncotarget 8:52304-52320(2017)

PubMed=30551515; DOI=10.1016/j.biopha.2018.11.109
Ryabaya O., Prokofieva A., Akasov R., Khochenkov D., Emelyanova M., Burov S., Markvicheva E., Inshakov A., Stepanova E.V.
Metformin increases antitumor activity of MEK inhibitor binimetinib in 2D and 3D models of human metastatic melanoma cells.
Biomed. Pharmacother. 109:2548-2560(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B6KE
Encyclopedic resources Wikidata; Q112129311
Entry history
Entry creation17-Mar-2022
Last entry update05-Oct-2023
Version number5