ID   Mel Z
AC   CVCL_B6KE
SY   mel Z
DR   cancercelllines; CVCL_B6KE
DR   Wikidata; Q112129311
RX   CelloPub=CLPUB00680;
RX   Patent=RU2390556;
RX   PubMed=16107020;
RX   PubMed=28881731;
RX   PubMed=30551515;
CC   Group: Patented cell line.
CC   Registration: Non-internationally recognized Depositary Authority, Russian Cell Culture Collection (RCCC); 711D.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (CelloPub=CLPUB00680; PubMed=28881731; PubMed=30551515).
CC   Derived from site: Metastatic; Interscapular region, hypodermis; UBERON=UBERON_8480066+UBERON_0002072.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   55Y
CA   Cancer cell line
DT   Created: 17-03-22; Last updated: 05-10-23; Version: 5
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RX   CelloPub=CLPUB00680;
RA   Mikhailova I.N., Baryshnikov A.Y., Morozova L.F., Burova O.S.,
RA   Shubina I.Z., Kovalevsky D.A., Voronina E.S., Treshalina H.M.,
RA   Lushnikova A.A., Tsyganova I.V., Mazurenko N.N.;
RT   "Human skin melanoma cell lines collection.";
RL   (In) Management of malignant melanoma; None X. (eds.); pp.6.1-6.6; SM Group; Dover (2016).
//
RX   Patent=RU2390556;
RA   Mikhailova I.N., Baryshnikov A.Y., Demidov L.V., Kiselev S.L.,
RA   Burova O.S., Morozova L.F., Vjacheslavovich S.I.;
RT   "Human melanoma cell line mel Z used for making anti-tumour vaccines.";
RL   Patent number RU2390556, 27-May-2010.
//
RX   PubMed=16107020;
RA   Mikhailova I.N., Lukashina M.I., Baryshnikov A.Y., Morozova L.F.,
RA   Burova O.S., Palkina T.N., Kozlov A.M., Golubeva V.A.,
RA   Cheremushkin E.A., Doroshenko M.B., Demidov L.V., Kiselev S.L.,
RA   Larin S.S., Georgiev G.P.;
RT   "Melanoma cell lines as the basis for antitumor vaccine preparation.";
RL   Vestn. Ross. Akad. Med. Nauk 2005:37-40(2005).
//
RX   PubMed=28881731; DOI=10.18632/oncotarget.17014;
RA   Emelyanova M., Ghukasyan L., Abramov I., Ryabaya O., Stepanova E.V.,
RA   Kudryavtseva A., Sadritdinova A., Dzhumakova C., Belysheva T.,
RA   Surzhikov S., Lyubchenko L., Zasedatelev A., Nasedkina T.;
RT   "Detection of BRAF, NRAS, KIT, GNAQ, GNA11 and MAP2K1/2 mutations in
RT   Russian melanoma patients using LNA PCR clamp and biochip analysis.";
RL   Oncotarget 8:52304-52320(2017).
//
RX   PubMed=30551515; DOI=10.1016/j.biopha.2018.11.109;
RA   Ryabaya O., Prokofieva A., Akasov R., Khochenkov D., Emelyanova M.,
RA   Burov S., Markvicheva E., Inshakov A., Stepanova E.V.;
RT   "Metformin increases antitumor activity of MEK inhibitor binimetinib
RT   in 2D and 3D models of human metastatic melanoma cells.";
RL   Biomed. Pharmacother. 109:2548-2560(2019).
//