Cellosaurus logo
expasy logo

Cellosaurus MLM #5 (CVCL_B6J6)

[Text version]
Cell line name MLM #5
Synonyms MLM#5; mEERL lung metastasis clone 5
Accession CVCL_B6J6
Resource Identification Initiative To cite this cell line use: MLM #5 (RRID:CVCL_B6J6)
Comments Characteristics: Established from lung tumors obtained after injection of the parent cell line into a mouse that was then treated with cisplatin/radiation therapy (CRT) (PubMed=27013584).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Firefly luciferase.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Pharynx, oropharynx; UBERON=UBERON_0001729.
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Parent: CVCL_B6J3 (mEERL)
Sex of cell Male
Age at sampling 6-8W
Category Transformed cell line
Publications

PubMed=27013584; DOI=10.18632/oncotarget.8254; PMCID=PMC5029694
Vermeer D.W., Coppock J.D., Zeng E.-L., Lee K.M., Spanos W.C., Onken M.D., Uppaluri R., Lee J.H., Vermeer P.D.
Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis.
Oncotarget 7:24194-24207(2016)

Cross-references
Encyclopedic resources Wikidata; Q112129335
Gene expression databases GEO; GSM1687311
GEO; GSM1687312
GEO; GSM1687313
GEO; GSM1687314
Entry history
Entry creation17-Mar-2022
Last entry update19-Dec-2024
Version number7