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Cellosaurus CM05287 (CVCL_B4ZP)

[Text version]
Cell line name CM05287
Accession CVCL_B4ZP
Resource Identification Initiative To cite this cell line use: CM05287 (RRID:CVCL_B4ZP)
Comments Karyotypic information: 60% trisomy 21, 40% normal karyotype (PubMed=25694335).
Omics: Transcriptome analysis by single cell RNAseq.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Disease Down syndrome (NCIt: C2993)
Down syndrome (ORDO: Orphanet_870)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_B4ZQ (NIZEDSM1iD21-C3)CVCL_B4ZR (NIZEDSM1iD21-C7)CVCL_B4ZS (NIZEDSM1iD21-C9)
CVCL_B4ZV (NIZEDSM1iT21-C13)CVCL_B4ZT (NIZEDSM1iT21-C5)CVCL_B4ZU (NIZEDSM1iT21-C6)
Age at sampling Adult
Category Finite cell line
Publications

PubMed=25694335; DOI=10.1002/stem.1968; PMCID=PMC4737213
Murray A., Letourneau A., Canzonetta C., Stathaki E., Gimelli S., Sloan-Bena F., Abrehart R., Goh P., Lim S., Baldo C., Dagna-Bricarelli F., Hannan S., Mortensen M., Ballard D., Syndercombe-Court D., Fusaki N., Hasegawa M., Smart T.G., Bishop C., Antonarakis S.E., Groet J., Nizetic D.
Brief report: isogenic induced pluripotent stem cell lines from an adult with mosaic Down syndrome model accelerated neuronal ageing and neurodegeneration.
Stem Cells 33:2077-2084(2015)

PubMed=31582743; DOI=10.1038/s41467-019-12273-8; PMCID=PMC6776538
Stamoulis G., Garieri M., Makrythanasis P., Letourneau A., Guipponi M., Panousis N.I., Sloan-Bena F., Falconnet E., Ribaux P., Borel C., Santoni F.A., Antonarakis S.E.
Single cell transcriptome in aneuploidies reveals mechanisms of gene dosage imbalance.
Nat. Commun. 10:4495.1-4495.11(2019)

Cross-references
Encyclopedic resources Wikidata; Q110432724
Gene expression databases GEO; GSE135500
Entry history
Entry creation16-Dec-2021
Last entry update29-Jun-2023
Version number4