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Cellosaurus ESKOL (CVCL_B398)

[Text version]
Cell line name ESKOL
Synonyms Eskol
Accession CVCL_B398
Resource Identification Initiative To cite this cell line use: ESKOL (RRID:CVCL_B398)
Comments Problematic cell line: Possibly misclassified. It is not certain that this cell line originate from a hairy cell leukemia (PubMed=22653958).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Disease Hairy cell leukemia (NCIt: C7402)
Classic hairy cell leukemia (ORDO: Orphanet_58017)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_W994 (IREs-4)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line

PubMed=1895754; DOI=10.1016/0145-2126(91)90077-7
Harvey W., Srour E.F., Turner R., Carey R., Maze R., Starrett B., Kanagala R., Pereira D., Merchant P., Taylor M.W., Jansen J.
Characterization of a new cell line (ESKOL) resembling hairy-cell leukemia: a model for oncogene regulation and late B-cell differentiation.
Leuk. Res. 15:733-744(1991)

PubMed=11060441; DOI=10.1159/000015656
Lindbjerg Andersen C., Ostergaard M., Nielsen B., Pedersen B., Koch J.
Characterization of three hairy cell leukemia- derived cell lines (ESKOL, JOK-1, and Hair-M) by multiplex-FISH, comparative genomic hybridization, FISH, PRINS, and dideoxyPRINS.
Cytogenet. Cell Genet. 90:30-39(2000)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=11755467; DOI=10.1016/S0145-2126(01)00100-X
Khalaf W., Maina C., Byers J., Harvey W.
Interferon-alpha 2b and vesnarinone influence levels of tumor necrosis factor-alpha, apoptosis, or interleukin 6 in ESKOL, a hairy cell leukemic cell line. A potential cytokine and oncogene relationship regulating apoptosis is suggested.
Leuk. Res. 26:169-177(2002)

PubMed=22653958; DOI=10.1182/blood-2011-12-400374
Tiacci E., Pucciarini A., Bigerna B., Pettirossi V., Strozzini F., Martelli M.P., Tabarrini A., Drexler H.G., Falini B.
Absence of BRAF-V600E in the human cell lines BONNA-12, ESKOL, HAIR-M, and HC-1 questions their origin from hairy cell leukemia.
Blood 119:5332-5333(2012)

Encyclopedic resources Wikidata; Q54832831
Gene expression databases GEO; GSM1374476
Polymorphism and mutation databases Cosmic; 1809510
Cosmic; 2690007
Entry history
Entry creation06-Jun-2012
Last entry update29-Jun-2023
Version number14