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Cellosaurus MEC (CVCL_B270)

[Text version]
Cell line name MEC
Accession CVCL_B270
Resource Identification Initiative To cite this cell line use: MEC (RRID:CVCL_B270)
Comments Population: Japanese.
Doubling time: 40.8 hours (PubMed=1965684).
Omics: CRISPR phenotypic screen.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Disease Cholangiocarcinoma (NCIt: C4436)
Cholangiocarcinoma (ORDO: Orphanet_70567)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
STR profile Source(s): RCB=RCB2129; TKG=TKG 0629

Markers:
AmelogeninX,Y
CSF1PO10,14
D5S81811,13
D7S8209.3,11 (TKG=TKG 0629)
11 (RCB=RCB2129)
D13S3178,11 (RCB=RCB2129)
9,11 (TKG=TKG 0629)
D16S5399,12
TH019.3
TPOX8,9
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=1965684
Yoshida K., Tomizawa H., Ota T., Nagashima T., Kikuchi H., Watanabe H., Hashizaki K., Yonaha A.
Establishment and characterization of human cholangiocarcinoma, MEC, producing carbohydrate antigen 19-9.
Hum. Cell 3:346-351(1990)

PubMed=21451941; DOI=10.1007/s00534-011-0376-7
Sato J., Kimura T., Saito T., Anazawa T., Kenjo A., Sato Y., Tsuchiya T., Gotoh M.
Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinoma.
J. Hepatobiliary Pancreat. Sci. 18:700-711(2011)

CLPUB00275
Zach S., Birgin E., Ruckert F.
Primary cholangiocellular carcinoma cell lines.
J. Stem Cell Res. Transplant. 2:1013-1013(2015)

PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007; PMCID=PMC9472155
Isidan A., Yenigun A., Soma D., Aksu E., Lopez K., Park Y., Cross-Najafi A., Li P., Kundu D., House M.G., Chakraborty S., Glaser S., Kennedy L., Francis H., Zhang W.-J., Alpini G.D., Ekser B.
Development and characterization of human primary cholangiocarcinoma cell lines.
Am. J. Pathol. 192:1200-1217(2022)

PubMed=36724073; DOI=10.1016/j.celrep.2023.112065
Yang J.-C., Guo F.-S., Chin H.-S., Chen G.-B., Ang C.-H., Lin Q.-S., Hong W.-J., Fu N.-Y.
Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.
Cell Rep. 42:112065.1-112065.26(2023)

Cross-references
Cell line collections (Providers) RCB; RCB2129 - Discontinued
TKG; TKG 0629
Biological sample resources BioSample; SAMN03472009
CRISP screens repositories BioGRID_ORCS_Cell_line; 1788
Encyclopedic resources Wikidata; Q54904994
Polymorphism and mutation databases Cosmic; 1122351
Entry history
Entry creation06-Jun-2012
Last entry update02-May-2024
Version number20