ID   MEC
AC   CVCL_B270
DR   BioGRID_ORCS_Cell_line; 1788
DR   BioSample; SAMN03472009
DR   Cosmic; 1122351
DR   RCB; RCB2129
DR   TKG; TKG 0629
DR   Wikidata; Q54904994
RX   CelloPub=CLPUB00275;
RX   PubMed=1965684;
RX   PubMed=21451941;
RX   PubMed=35640676;
RX   PubMed=36724073;
CC   Population: Japanese.
CC   Doubling time: 40.8 hours (PubMed=1965684).
CC   Omics: CRISPR phenotypic screen.
CC   Discontinued: RCB; RCB2129; true.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): RCB=RCB2129; TKG=TKG 0629
ST   Amelogenin: X,Y
ST   CSF1PO: 10,14
ST   D13S317: 8,11 (RCB=RCB2129)
ST   D13S317: 9,11 (TKG=TKG 0629)
ST   D16S539: 9,12
ST   D5S818: 11,13
ST   D7S820: 9.3,11 (TKG=TKG 0629)
ST   D7S820: 11 (RCB=RCB2129)
ST   TH01: 9.3
ST   TPOX: 8,9
ST   vWA: 17,18
DI   NCIt; C4436; Cholangiocarcinoma
DI   ORDO; Orphanet_70567; Cholangiocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   68Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 02-05-24; Version: 20
//
RX   CelloPub=CLPUB00275;
RA   Zach S., Birgin E., Ruckert F.;
RT   "Primary cholangiocellular carcinoma cell lines.";
RL   J. Stem Cell Res. Transplant. 2:1013-1013(2015).
//
RX   PubMed=1965684;
RA   Yoshida K., Tomizawa H., Ota T., Nagashima T., Kikuchi H.,
RA   Watanabe H., Hashizaki K., Yonaha A.;
RT   "Establishment and characterization of human cholangiocarcinoma, MEC,
RT   producing carbohydrate antigen 19-9.";
RL   Hum. Cell 3:346-351(1990).
//
RX   PubMed=21451941; DOI=10.1007/s00534-011-0376-7;
RA   Sato J., Kimura T., Saito T., Anazawa T., Kenjo A., Sato Y.,
RA   Tsuchiya T., Gotoh M.;
RT   "Gene expression analysis for predicting gemcitabine resistance in
RT   human cholangiocarcinoma.";
RL   J. Hepatobiliary Pancreat. Sci. 18:700-711(2011).
//
RX   PubMed=35640676; DOI=10.1016/j.ajpath.2022.05.007; PMCID=PMC9472155;
RA   Isidan A., Yenigun A., Soma D., Aksu E., Lopez K., Park Y.,
RA   Cross-Najafi A., Li P., Kundu D., House M.G., Chakraborty S.,
RA   Glaser S., Kennedy L., Francis H., Zhang W.-J., Alpini G.D., Ekser B.;
RT   "Development and characterization of human primary cholangiocarcinoma
RT   cell lines.";
RL   Am. J. Pathol. 192:1200-1217(2022).
//
RX   PubMed=36724073; DOI=10.1016/j.celrep.2023.112065;
RA   Yang J.-C., Guo F.-S., Chin H.-S., Chen G.-B., Ang C.-H., Lin Q.-S.,
RA   Hong W.-J., Fu N.-Y.;
RT   "Sequential genome-wide CRISPR-Cas9 screens identify genes regulating
RT   cell-surface expression of tetraspanins.";
RL   Cell Rep. 42:112065.1-112065.26(2023).
//