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Cellosaurus PC/JW (CVCL_B262)

[Text version]
Cell line name PC/JW
Synonyms PC-JW; PCJW; JW
Accession CVCL_B262
Resource Identification Initiative To cite this cell line use: PC/JW (RRID:CVCL_B262)
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Omics: Deep proteome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; c.74+1G>A; Zygosity=Unspecified; Note=Splice donor mutation (PubMed=16418264).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_IQ10 (PC/JW/FI)
Sex of cell Female
Age at sampling 30Y
Category Cancer cell line
Publications

PubMed=6746117; DOI=10.1002/ijc.2910340109
Paraskeva C., Buckle B.G., Sheer D., Wigley C.B.
The isolation and characterization of colorectal epithelial cell lines at different stages in malignant transformation from familial polyposis coli patients.
Int. J. Cancer 34:49-56(1984)

PubMed=2253215
Baker S.J., Preisinger A.C., Jessup J.M., Paraskeva C., Markowitz S.D., Willson J.K.V., Hamilton S.R., Vogelstein B.
p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.
Cancer Res. 50:7717-7722(1990)

PubMed=8464898; DOI=10.1073/pnas.90.7.2842
Browning M.J., Krausa P., Rowan A.J., Bicknell D.C., Bodmer J.G., Bodmer W.F.
Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines.
Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993)

PubMed=16418264; DOI=10.1073/pnas.0510146103
Liu Y., Bodmer W.F.
Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=18258742; DOI=10.1073/pnas.0712176105
Emaduddin M., Bicknell D.C., Bodmer W.F., Feller S.M.
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780
Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=23272949; DOI=10.1186/1755-8794-5-66
Schlicker A., Beran G., Chresta C.M., McWalter G., Pritchard A., Weston S., Runswick S., Davenport S., Heathcote K., Castro D.A., Orphanides G., French T., Wessels L.F.A.
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med. Genomics 5:66.1-66.15(2012)

PubMed=29101300; DOI=10.15252/msb.20177701
Frejno M., Zenezini Chiozzi R., Wilhelm M., Koch H., Zheng R.-S., Klaeger S., Ruprecht B., Meng C., Kramer K., Jarzab A., Heinzlmeir S., Johnstone E., Domingo E., Kerr D., Jesinghaus M., Slotta-Huspenina J., Weichert W., Knapp S., Feller S.M., Kuster B.
Pharmacoproteomic characterisation of human colon and rectal cancer.
Mol. Syst. Biol. 13:951-951(2017)

Cross-references
Encyclopedic resources Wikidata; Q54938520
Gene expression databases GEO; GSM1374825
Polymorphism and mutation databases Cosmic; 876725
Cosmic; 948837
Cosmic; 1043823
Cosmic; 1312308
Cosmic; 2760079
Cosmic; 2800582
IARC_TP53; 21709
IARC_TP53; 21755
Proteomic databases PRIDE; PXD005354
PRIDE; PXD005355
Entry history
Entry creation06-Jun-2012
Last entry update29-Jun-2023
Version number18