ID   PC/JW
AC   CVCL_B262
SY   PC-JW; PCJW; JW
DR   Cosmic; 876725
DR   Cosmic; 948837
DR   Cosmic; 1043823
DR   Cosmic; 1312308
DR   Cosmic; 2760079
DR   Cosmic; 2800582
DR   GEO; GSM1374825
DR   IARC_TP53; 21709
DR   IARC_TP53; 21755
DR   PRIDE; PXD005354
DR   PRIDE; PXD005355
DR   Wikidata; Q54938520
RX   PubMed=2253215;
RX   PubMed=6746117;
RX   PubMed=8464898;
RX   PubMed=16418264;
RX   PubMed=18258742;
RX   PubMed=20606684;
RX   PubMed=23272949;
RX   PubMed=29101300;
CC   Part of: AstraZeneca Colorectal cell line (AZCL) panel.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.74+1G>A; Zygosity=Unspecified; Note=Splice donor mutation (PubMed=16418264).
CC   Omics: Deep proteome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
CC   Cell type: Epithelial cell of colon; CL=CL_0011108.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   30Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 29-06-23; Version: 18
//
RX   PubMed=2253215;
RA   Baker S.J., Preisinger A.C., Jessup J.M., Paraskeva C., Markowitz S.D.,
RA   Willson J.K.V., Hamilton S.R., Vogelstein B.;
RT   "p53 gene mutations occur in combination with 17p allelic deletions as
RT   late events in colorectal tumorigenesis.";
RL   Cancer Res. 50:7717-7722(1990).
//
RX   PubMed=6746117; DOI=10.1002/ijc.2910340109;
RA   Paraskeva C., Buckle B.G., Sheer D., Wigley C.B.;
RT   "The isolation and characterization of colorectal epithelial cell
RT   lines at different stages in malignant transformation from familial
RT   polyposis coli patients.";
RL   Int. J. Cancer 34:49-56(1984).
//
RX   PubMed=8464898; DOI=10.1073/pnas.90.7.2842;
RA   Browning M.J., Krausa P., Rowan A.J., Bicknell D.C., Bodmer J.G.,
RA   Bodmer W.F.;
RT   "Tissue typing the HLA-A locus from genomic DNA by sequence-specific
RT   PCR: comparison of HLA genotype and surface expression on colorectal
RT   tumor cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993).
//
RX   PubMed=16418264; DOI=10.1073/pnas.0510146103;
RA   Liu Y., Bodmer W.F.;
RT   "Analysis of P53 mutations and their expression in 56 colorectal
RT   cancer cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006).
//
RX   PubMed=18258742; DOI=10.1073/pnas.0712176105;
RA   Emaduddin M., Bicknell D.C., Bodmer W.F., Feller S.M.;
RT   "Cell growth, global phosphotyrosine elevation, and c-Met
RT   phosphorylation through Src family kinases in colorectal cancer
RT   cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008).
//
RX   PubMed=20606684; DOI=10.1038/sj.bjc.6605780;
RA   Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.;
RT   "5-fluorouracil response in a large panel of colorectal cancer cell
RT   lines is associated with mismatch repair deficiency.";
RL   Br. J. Cancer 103:340-346(2010).
//
RX   PubMed=23272949; DOI=10.1186/1755-8794-5-66;
RA   Schlicker A., Beran G., Chresta C.M., McWalter G., Pritchard A.,
RA   Weston S., Runswick S., Davenport S., Heathcote K., Castro D.A.,
RA   Orphanides G., French T., Wessels L.F.A.;
RT   "Subtypes of primary colorectal tumors correlate with response to
RT   targeted treatment in colorectal cell lines.";
RL   BMC Med. Genomics 5:66.1-66.15(2012).
//
RX   PubMed=29101300; DOI=10.15252/msb.20177701;
RA   Frejno M., Zenezini Chiozzi R., Wilhelm M., Koch H., Zheng R.-S.,
RA   Klaeger S., Ruprecht B., Meng C., Kramer K., Jarzab A., Heinzlmeir S.,
RA   Johnstone E., Domingo E., Kerr D., Jesinghaus M., Slotta-Huspenina J.,
RA   Weichert W., Knapp S., Feller S.M., Kuster B.;
RT   "Pharmacoproteomic characterisation of human colon and rectal
RT   cancer.";
RL   Mol. Syst. Biol. 13:951-951(2017).
//