Cellosaurus cell line NIKS-16 (CVCL

Cellosaurus NIKS-16 (CVCL_B0UM)

Cross-references
Cell line name	NIKS-16
Synonyms	NIKS16; BC-1-Ep/SL/HPV-16
Accession	CVCL_B0UM
Resource Identification Initiative	To cite this cell line use: NIKS-16 (RRID:CVCL_B0UM)
Comments	Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16). Omics: Transcriptome analysis by microarray. Omics: Transcriptome analysis by RNAseq. Derived from site: In situ; Foreskin, skin, epidermis; UBERON=UBERON_0001471+UBERON_0001003. Cell type: Keratinocyte; CL=CL_0000312.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_A1LW (NIKS)
Sex of cell	Male
Age at sampling	<1M
Category	Transformed cell line
Publications	PubMed=10864676; DOI=10.1128/JVI.74.14.6622-6631.2000; PMCID=PMC112172 Flores E.R., Allen-Hoffmann B.L., Lee D.L., Lambert P.F. The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle. J. Virol. 74:6622-6631(2000) PubMed=28623356; DOI=10.1038/s41598-017-03295-7; PMCID=PMC5473897 Cicchini L., Blumhagen R.Z., Westrich J.A., Myers M.E., Warren C.J., Siska C., Raben D., Kechris K.J., Pyeon D. High-risk human papillomavirus E7 alters host DNA methylome and represses HLA-E expression in human keratinocytes. Sci. Rep. 7:3633-3633(2017) PubMed=29021401; DOI=10.1128/JVI.01001-17; PMCID=PMC5709591 Klymenko T., Gu Q., Herbert I., Stevenson A., Iliev V., Watkins G., Pollock C.S., Bhatia R., Cuschieri K., Herzyk P., Gatherer D., Graham S.V. RNA-Seq analysis of differentiated keratinocytes reveals a massive response to late events during human papillomavirus 16 infection, including loss of epithelial barrier function. J. Virol. 91:e01001.17.1-e01001.17.17(2017)
Encyclopedic resources	Wikidata; Q108821045
Gene expression databases	GEO; GSM2197775 GEO; GSM2197776 GEO; GSM2197777
Entry history
Entry creation	23-Sep-2021
Last entry update	10-Sep-2024
Version number	5