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Cellosaurus UWB1.289+BRCA1 (CVCL_B078)

[Text version]
Cell line name UWB1.289+BRCA1
Accession CVCL_B078
Resource Identification Initiative To cite this cell line use: UWB1.289+BRCA1 (RRID:CVCL_B078)
Comments Part of: OCCP ovarian cancer cell line panel.
Population: Caucasian.
Characteristics: Due to the high expression of the transfected wild-type BRCA1 gene, this cell line is partially rescued in term of its response to DNA damage.
Doubling time: 20.0 hours (PubMed=17259345); ~36 hours (ATCC=CRL-2946).
Transfected with: HGNC; 1100; BRCA1.
Omics: Transcriptome analysis by microarray.
Sequence variations
  • Gene deletion; HGNC; 1100; BRCA1; Zygosity=Heterozygous (PubMed=17259345).
  • Mutation; HGNC; 1100; BRCA1; Simple; p.Asp825Glufs*21 (c.2475delC); ClinVar=VCV000037472; Zygosity=Heterozygous (PubMed=17259345).
Disease BRCA1-associated hereditary breast and ovarian cancer syndrome (NCIt: C36100)
Hereditary breast and ovarian cancer syndrome (ORDO: Orphanet_145)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B079 (UWB1.289)
Sex of cell Female
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): ATCC; PubMed=25230021

Markers:
AmelogeninX
CSF1PO11
D3S135814,15
D5S81813
D7S8207,10
D8S117912
D13S3179
D16S53912
D18S5119
D21S1128,31
FGA22
Penta D10
Penta E8
TH019
TPOX9,11
vWA16,19

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Publications

PubMed=17259345; DOI=10.1158/1541-7786.MCR-06-0234
DelloRusso C., Welcsh P.L., Wang W.-X., Garcia R.L., King M.-C., Swisher E.M.
Functional characterization of a novel BRCA1-null ovarian cancer cell line in response to ionizing radiation.
Mol. Cancer Res. 5:35-45(2007)

PubMed=25230021; DOI=10.1371/journal.pone.0103988
Beaufort C.M., Helmijr J.C.A., Piskorz A.M., Hoogstraat M., Ruigrok-Ritstier K., Besselink N., Murtaza M., van IJcken W.F.J., Heine A.A.J., Smid M., Koudijs M.J., Brenton J.D., Berns E.M.J.J., Helleman J.
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
PLoS ONE 9:E103988-E103988(2014)

Cross-references
Cell line collections (Providers) ATCC; CRL-2946
Anatomy/cell type resources BTO; BTO:0006254
Encyclopedic resources Wikidata; Q54992391
Gene expression databases GEO; GSM1291154
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number15