Cellosaurus cell line UWB1.289+BRCA1 (CVCL

Cellosaurus UWB1.289+BRCA1 (CVCL_B078)

[Text version]

Cell line name

UWB1.289+BRCA1

Accession

CVCL_B078

Resource Identification Initiative

To cite this cell line use: UWB1.289+BRCA1 (RRID:CVCL_B078)

Comments

Part of: OCCP ovarian cancer cell line panel.
Population: Caucasian.
Characteristics: Due to the high expression of the transfected wild-type BRCA1 gene, this cell line is partially rescued in term of its response to DNA damage.
Doubling time: 20.0 hours (PubMed=17259345); ~36 hours (ATCC=CRL-2946).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1100; BRCA1.
Omics: Transcriptome analysis by microarray.

Sequence variations

Gene deletion; HGNC; HGNC:1100; BRCA1; Zygosity=Heterozygous (PubMed=17259345).
Mutation; HGNC; HGNC:1100; BRCA1; Simple; p.Asp825Glufs*21 (c.2475delC); ClinVar=VCV000037472; Zygosity=Heterozygous (PubMed=17259345).

Disease

BRCA1-associated hereditary breast and ovarian cancer syndrome (NCIt: C36100)
Hereditary breast and ovarian cancer syndrome (ORDO: Orphanet_145)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_B079 (UWB1.289)

Sex of cell

Female

Age at sampling

56Y

Category

Cancer cell line

STR profile

Source(s): ATCC=CRL-2946; PubMed=25230021

Markers:

Amelogenin	X
CSF1PO	11
D2S1338	19
D3S1358	14,15
D5S818	13
D7S820	7,10
D8S1179	12
D13S317	9
D16S539	12
D18S51	19
D19S433	14,15
D21S11	28,31
FGA	22
Penta D	10
Penta E	8
TH01	9
TPOX	9,11
vWA	16,19

Publications

PubMed=17259345; DOI=10.1158/1541-7786.MCR-06-0234
DelloRusso C., Welcsh P.L., Wang W.-X., Garcia R.L., King M.-C., Swisher E.M.
Functional characterization of a novel BRCA1-null ovarian cancer cell line in response to ionizing radiation.
Mol. Cancer Res. 5:35-45(2007)

PubMed=25230021; DOI=10.1371/journal.pone.0103988; PMCID=PMC4167545
Beaufort C.M., Helmijr J.C.A., Piskorz A.M., Hoogstraat M., Ruigrok-Ritstier K., Besselink N., Murtaza M., van IJcken W.F.J., Heine A.A.J., Smid M., Koudijs M.J., Brenton J.D., Berns E.M.J.J., Helleman J.
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
PLoS ONE 9:E103988-E103988(2014)

Cross-references

Cell line collections (Providers)

ATCC; CRL-2946

Anatomy/cell type resources

BTO; BTO_0006254

Encyclopedic resources

Wikidata; Q54992391

Gene expression databases

GEO; GSM1291154

Entry history

Entry creation

06-Jun-2012

Last entry update

19-Dec-2024

Version number