ID   UWB1.289+BRCA1
AC   CVCL_B078
DR   BTO; BTO:0006254
DR   ATCC; CRL-2946
DR   GEO; GSM1291154
DR   Wikidata; Q54992391
RX   PubMed=17259345;
RX   PubMed=25230021;
CC   Part of: OCCP ovarian cancer cell line panel.
CC   Population: Caucasian.
CC   Characteristics: Due to the high expression of the transfected wild-type BRCA1 gene, this cell line is partially rescued in term of its response to DNA damage.
CC   Doubling time: 20.0 hours (PubMed=17259345); ~36 hours (ATCC=CRL-2946).
CC   Sequence variation: Gene deletion; HGNC; 1100; BRCA1; Zygosity=Heterozygous (PubMed=17259345).
CC   Sequence variation: Mutation; HGNC; 1100; BRCA1; Simple; p.Asp825Glufs*21 (c.2475delC); ClinVar=VCV000037472; Zygosity=Heterozygous (PubMed=17259345).
CC   Transfected with: HGNC; 1100; BRCA1.
CC   Omics: Transcriptome analysis by microarray.
ST   Source(s): ATCC=CRL-2946; PubMed=25230021
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 9
ST   D16S539: 12
ST   D18S51: 19
ST   D19S433: 14,15
ST   D21S11: 28,31
ST   D2S1338: 19
ST   D3S1358: 14,15
ST   D5S818: 13
ST   D7S820: 7,10
ST   D8S1179: 12
ST   FGA: 22
ST   Penta D: 10
ST   Penta E: 8
ST   TH01: 9
ST   TPOX: 9,11
ST   vWA: 16,19
DI   NCIt; C36100; BRCA1-associated hereditary breast and ovarian cancer syndrome
DI   ORDO; Orphanet_145; Hereditary breast and ovarian cancer syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_B079 ! UWB1.289
SX   Female
AG   56Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 02-05-24; Version: 16
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RX   PubMed=17259345; DOI=10.1158/1541-7786.MCR-06-0234;
RA   DelloRusso C., Welcsh P.L., Wang W.-X., Garcia R.L., King M.-C.,
RA   Swisher E.M.;
RT   "Functional characterization of a novel BRCA1-null ovarian cancer cell
RT   line in response to ionizing radiation.";
RL   Mol. Cancer Res. 5:35-45(2007).
//
RX   PubMed=25230021; DOI=10.1371/journal.pone.0103988;
RA   Beaufort C.M., Helmijr J.C.A., Piskorz A.M., Hoogstraat M.,
RA   Ruigrok-Ritstier K., Besselink N., Murtaza M., van IJcken W.F.J.,
RA   Heine A.A.J., Smid M., Koudijs M.J., Brenton J.D., Berns E.M.J.J.,
RA   Helleman J.;
RT   "Ovarian cancer cell line panel (OCCP): clinical importance of in
RT   vitro morphological subtypes.";
RL   PLoS ONE 9:E103988-E103988(2014).
//