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Cellosaurus HT1080 FUS-DDIT3-EGFP (CVCL_AX37)

[Text version]
Cell line name HT1080 FUS-DDIT3-EGFP
Synonyms HT1080_FUS-DDIT3-EGFP
Accession CVCL_AX37
Resource Identification Initiative To cite this cell line use: HT1080 FUS-DDIT3-EGFP (RRID:CVCL_AX37)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 2726; DDIT3 (Note=FUS-DDIT3 fusion).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 4010; FUS (Note=FUS-DDIT3 fusion).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0317 (HT-1080)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Publications

PubMed=16651630; DOI=10.2353/ajpath.2006.050872; PMCID=PMC1606602
Engstrom K., Willen H., Kabjorn-Gustafsson C., Andersson C., Olsson M., Goransson M., Thelin-Jarnum S., Olofsson A., Warnhammar E., Aman P.
The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype in transfected human fibrosarcoma cells.
Am. J. Pathol. 168:1642-1653(2006)

PubMed=25393000; DOI=10.1371/journal.pone.0113110; PMCID=PMC4231113
Stahlberg A., Kabjorn-Gustafsson C., Engtrom K., Thomsen C., Dolatabadi S., Jonasson E., Li C.-Y., Ruff D., Chen S.-M., Aman P.
Normal and functional TP53 in genetically stable myxoid/round cell liposarcoma.
PLoS ONE 9:E113110-E113110(2014)

PubMed=30962207; DOI=10.15252/embr.201845766; PMCID=PMC6500973
Linden M., Thomsen C., Grundevik P., Jonasson E., Andersson D., Runnberg R., Dolatabadi S., Vannas C., Santamaria M.L., Fagman H., Stahlberg A., Aman P.
FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex.
EMBO Rep. 20:e45766.1-e45766.15(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_AX37
Encyclopedic resources Wikidata; Q54896556
Gene expression databases GEO; GSM3585519
GEO; GSM3585520
GEO; GSM3585521
Entry history
Entry creation02-May-2016
Last entry update10-Sep-2024
Version number18