Cellosaurus HeLa-Mitotrap (CVCL_AR66)
| Cell line name | HeLa-Mitotrap | |||
|---|---|---|---|---|
| Accession | CVCL_AR66 | |||
| Resource Identification Initiative | To cite this cell line use: HeLa-Mitotrap (RRID:CVCL_AR66) | |||
| Comments | Population: African American. Characteristics: Can be used to determine the function of a protein by rapidly inactivating the protein of interest by rapamycin-induced rerouting to the mitochondria. This process is termed 'knocksideway'. Characteristics: Transfected with Mitotrap, a construct composed of the import signal of yeast TOM70, a YFP and the rapamycin-binding (FRB) domain from MTOR. Genetic integration: Method=Transfection/transduction; Gene=HGNC; 3942; MTOR (Note=With Met1_Arg2018del and Gln2114_Trp2549del = FRB). Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18). Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002. | |||
| Disease | Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677) | |||
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | |||
| Hierarchy | Parent: CVCL_R965 (HeLa M) Children:
| |||
| Sex of cell | Female | |||
| Age at sampling | 30Y6M | |||
| Category | Cancer cell line | |||
| Web pages | http://www.enterprise.cam.ac.uk/reagents/hela-mitotrap-cell-lines/ | |||
| Publications | PubMed=20159602; DOI=10.1016/j.devcel.2009.12.015; PMCID=PMC2845799 | |||
| Cross-references | ||||
| Cell line collections (Providers) | ECACC; 15042201
Ximbio; 152426 | |||
| Encyclopedic resources | Wikidata; Q54882721 | |||
| Entry history | ||||
| Entry creation | 02-May-2016 | |||
| Last entry update | 10-Sep-2024 | |||
| Version number | 13 | |||