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Cellosaurus LA-350 (CVCL_AR50)

[Text version]
Cell line name LA-350
Synonyms LA 350; LA350
Accession CVCL_AR50
Resource Identification Initiative To cite this cell line use: LA-350 (RRID:CVCL_AR50)
Comments From: Seeger, Robert C.; UCLA Center for Health Sciences; Los Angeles; USA.
Characteristics: Secretes IgM kappa.
Doubling time: 12-18 hours (PubMed=3033590).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Miscellaneous: On the basis that LA-350 and LA-N-5 (Cellosaurus=CVCL_0389) are both established by Seeger R.C., that they share identical STR profiles and that LA-350 is said to originate from a patient suffering from neuroblastoma we have annotated them as being autologous cell lines.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_0389 ! LA-N-5
Sex of cell Male
Age at sampling 4M
Category Transformed cell line
STR profile Source(s): COG

Markers:
AmelogeninX,Y
CSF1PO10,11
D2S133819,25
D3S135815,16
D5S81811
D7S82010
D8S117911,13
D13S3179,12
D16S5399,12
D18S5117,22
D19S43313,15
D21S1129,31
FGA21,27
TH016,9.3
TPOX8
vWA15,16

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Publications

PubMed=3033590; DOI=10.1203/00006450-198704000-00003
Rosenblatt H.M., Lewis D.E., Sklar J., Cleary M.L., Parikh N., Galili N., Ritz J., Shearer W.T.
Epstein-Barr virus-transformed B-cell line (DV-1) derived from bone marrow of a patient with severe combined immunodeficiency and immunoblastic lymphoma.
Pediatr. Res. 21:331-337(1987)

PubMed=2827896; DOI=10.1016/0008-8749(88)90095-0
Shearer W.T., Gilliam E.B., Rosenblatt H.M., Orson F.M.
I. Anti-mu antibody stimulates the phosphatidylinositol cycle and immunoglobulin secretion in a human lymphoblastoid B-cell line, LA350.
Cell. Immunol. 111:296-315(1988)

PubMed=3257418; DOI=10.1016/0008-8749(88)90096-2
Shearer W.T., Gilliam E.B., Rosenblatt H.M., Barron K.S., Orson F.M.
II. Phorbol ester binding to a human lymphoblastoid B-cell line, LA350, stimulates 32P incorporation into selected phospholipids and immunoglobulin secretion.
Cell. Immunol. 111:316-331(1988)

PubMed=1643757; DOI=10.1016/0090-1229(92)90205-3
Renz H., Or R., Domenico J., Leung D.Y.M., Gelfand E.W.
Reciprocal regulatory effects of IL-4 on cell growth and immunoglobulin production in Ig-secreting human B-cell lines.
Clin. Immunol. Immunopathol. 64:233-241(1992)

Cross-references
Encyclopedic resources Wikidata; Q54901865
Entry history
Entry creation02-May-2016
Last entry update10-Sep-2024
Version number9