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Cellosaurus CHLA-06-ATRT (CVCL_AQ42)

[Text version]
Cell line name CHLA-06-ATRT
Synonyms CHLA06ATRT; CHLA-06
Accession CVCL_AQ42
Resource Identification Initiative To cite this cell line use: CHLA-06-ATRT (RRID:CVCL_AQ42)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Omics: Deep exome analysis.
Derived from site: In situ; Brain, cerebellum; UBERON=UBERON_0002037.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.His178Asp (c.532C>G); ClinVar=VCV000482223; Zygosity=Unspecified (DepMap).
Disease Atypical teratoid/rhabdoid tumor (NCIt: C6906)
Atypical teratoid rhabdoid tumor (ORDO: Orphanet_99966)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 4M
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO11
D5S81811
D7S82011,13
D13S31713,14
D16S53911,12
TH017
TPOX12
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=24300787; DOI=10.1158/1078-0432.CCR-13-2053
Erdreich-Epstein A., Robison N., Ren X.-H., Zhou H., Xu J.-Y., Davidson T.B., Schur M., Gilles F.H., Ji L.-Y., Malvar J., Shackleford G.M., Margol A.S., Krieger M.D., Judkins A.R., Jones D.T.W., Pfister S.M., Kool M., Sposto R., Asgharzadeh S.
PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas.
Clin. Cancer Res. 20:827-836(2014)

PubMed=25211508; DOI=10.1002/jcb.24976
Xu J., Margol A.S., Asgharzadeh S., Erdreich-Epstein A.
Pediatric brain tumor cell lines.
J. Cell. Biochem. 116:218-224(2015)

PubMed=25246426; DOI=10.1093/neuonc/nou229
Chakravadhanula M., Hampton C.N., Chodavadia P., Ozols V., Zhou L., Catchpoole D., Xu J.-Y., Erdreich-Epstein A., Bhardwaj R.D.
Wnt pathway in atypical teratoid rhabdoid tumors.
Neuro-oncol. 17:526-535(2015)

PubMed=25638158; DOI=10.18632/oncotarget.3078
Weingart M.F., Roth J.J., Hutt-Cabezas M., Busse T.M., Kaur H., Price A., Maynard R., Rubens J., Taylor I.C., Mao X.-G., Xu J.-Y., Kuwahara Y., Allen S.J., Erdreich-Epstein A., Weissman B.E., Orr B.A., Eberhart C.G., Biegel J.A., Raabe E.H.
Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target.
Oncotarget 6:3165-3177(2015)

Cross-references
Cell line collections (Providers) ATCC; CRL-3038
Cell line databases/resources cancercelllines; CVCL_AQ42
Cell_Model_Passport; SIDM01550
DepMap; ACH-001028
Encyclopedic resources Wikidata; Q54812146
Entry history
Entry creation02-May-2016
Last entry update05-Oct-2023
Version number12