Cellosaurus cell line COG-N-415 (CVCL

Cellosaurus COG-N-415 (CVCL_AQ23)

[Text version]

Cell line name

COG-N-415

Synonyms

COGN415

Accession

CVCL_AQ23

Resource Identification Initiative

To cite this cell line use: COG-N-415 (RRID:CVCL_AQ23)

Comments

Doubling time: 50 hours (COG).
Omics: Chromatin accessibility by ATAC-seq.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: H3K27me3 ChIP-seq epigenome analysis.
Omics: H3K4me1 ChIP-seq epigenome analysis.
Omics: H3K4me3 ChIP-seq epigenome analysis.
Omics: Transcriptome analysis by RNAseq.

Sequence variations

Mutation; HGNC; HGNC:427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Unspecified (PubMed=28350380).

Disease

Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Sex unspecified

Age at sampling

Category

Cancer cell line

STR profile

Source(s): COG

Markers:

Amelogenin	X
CSF1PO	10,11
D2S1338	19,21
D3S1358	14,15
D5S818	11
D7S820	9,10
D8S1179	11,13,14
D13S317	11,12
D16S539	11
D18S51	12,15
D19S433	14,15
D21S11	28,29
FGA	19,22
TH01	7,8
TPOX	11
vWA	17

Publications

PubMed=24792489; DOI=10.1007/s11060-014-1456-8
Farooqi A.S., Dagg R.A., Choi L.M.R., Shay J.W., Reynolds C.P., Lau L.M.S.
Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations.
J. Neurooncol. 119:17-26(2014)

PubMed=28340497; DOI=10.1002/ijc.30706
Lopez-Barcons L., Maurer B.J., Kang M.H., Reynolds C.P.
P450 inhibitor ketoconazole increased the intratumor drug levels and antitumor activity of fenretinide in human neuroblastoma xenograft models.
Int. J. Cancer 141:405-413(2017)

PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315
Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L., Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033-170033(2017)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_AQ23

Encyclopedic resources

Wikidata; Q54814023

Gene expression databases

GEO; GSM2371224
GEO; GSM4104571
GEO; GSM4104572
GEO; GSM4104624
GEO; GSM4104625
GEO; GSM4105303
GEO; GSM4105304
GEO; GSM4105305
GEO; GSM4105306
GEO; GSM4105307

Entry history

Entry creation

02-May-2016

Last entry update

19-Dec-2024

Version number