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Cellosaurus GIST430B (CVCL_A9N1)

[Text version]
Cell line name GIST430B
Accession CVCL_A9N1
Resource Identification Initiative To cite this cell line use: GIST430B (RRID:CVCL_A9N1)
Comments Characteristics: Has lost KIT protein expression (PubMed=30488756).
Selected for resistance to: ChEBI; CHEBI_45783; Imatinib (Gleevec; STI571).
Omics: H3K27ac ChIP-seq epigenome analysis.
Cell type: Interstitial cell of Cajal; CL=CL_0002088.
Sequence variations
  • Mutation; HGNC; HGNC:6342; KIT; Simple; p.Val560_Leu576del (c.1678_1728del); ClinVar=VCV000523644; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6342; KIT; Simple; p.Val654Ala (c.1961T>C); ClinVar=VCV000375921; Zygosity=Heterozygous (from parent cell line).
Disease Gastrointestinal stromal tumor (NCIt: C3868)
Gastrointestinal stromal tumor (ORDO: Orphanet_44890)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7040 (GIST430)
Category Cancer cell line
Publications

PubMed=29866822; DOI=10.1073/pnas.1802079115; PMCID=PMC6016782
Hemming M.L., Lawlor M.A., Zeid R., Lesluyes T., Fletcher J.A., Raut C.P., Sicinska E.T., Chibon F., Armstrong S.A., Demetri G.D., Bradner J.E.
Gastrointestinal stromal tumor enhancers support a transcription factor network predictive of clinical outcome.
Proc. Natl. Acad. Sci. U.S.A. 115:E5746-E5755(2018)

PubMed=30488756; DOI=10.1080/15384101.2018.1553335; PMCID=PMC6300111
Tu Y.-Q., Zuo R., Ni N., Eilers G., Wu D.-L., Pei Y.-T., Nie Z.-M., Wu Y.-Q., Wu Y.-H., Ou W.-B.
Activated tyrosine kinases in gastrointestinal stromal tumor with loss of KIT oncoprotein expression.
Cell Cycle 17:2577-2592(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A9N1
Encyclopedic resources Wikidata; Q102113883
Gene expression databases GEO; GSM2527266
GEO; GSM2527267
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number7