ID   GIST430B
AC   CVCL_A9N1
DR   cancercelllines; CVCL_A9N1
DR   GEO; GSM2527266
DR   GEO; GSM2527267
DR   Wikidata; Q102113883
RX   PubMed=29866822;
RX   PubMed=30488756;
CC   Characteristics: Has lost KIT protein expression (PubMed=30488756).
CC   Selected for resistance to: ChEBI; CHEBI_45783; Imatinib (Gleevec; STI571).
CC   Sequence variation: Mutation; HGNC; HGNC:6342; KIT; Simple; p.Val560_Leu576del (c.1678_1728del); ClinVar=VCV000523644; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6342; KIT; Simple; p.Val654Ala (c.1961T>C); ClinVar=VCV000375921; Zygosity=Heterozygous (from parent cell line).
CC   Omics: Genomics; ChIP-seq; H3K27ac.
CC   Cell type: Interstitial cell of Cajal; CL=CL_0002088.
DI   NCIt; C3868; Gastrointestinal stromal tumor
DI   ORDO; Orphanet_44890; Gastrointestinal stromal tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_7040 ! GIST430
CA   Cancer cell line
DT   Created: 29-10-20; Last updated: 10-04-25; Version: 8
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RX   PubMed=29866822; DOI=10.1073/pnas.1802079115; PMCID=PMC6016782;
RA   Hemming, Matthew L.
RA   Lawlor, Matthew A.
RA   Zeid, Rhamy
RA   Lesluyes, Tom
RA   Fletcher, Jonathan A.
RA   Raut, Chandrajit P.
RA   Sicinska, Ewa T.
RA   Chibon, Frederic
RA   Armstrong, Scott Allen
RA   Demetri, George Daniel
RA   Bradner, James E.
RT   "Gastrointestinal stromal tumor enhancers support a transcription
RT   factor network predictive of clinical outcome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 115:E5746-E5755(2018).
//
RX   PubMed=30488756; DOI=10.1080/15384101.2018.1553335; PMCID=PMC6300111;
RA   Tu, Yu-Qing
RA   Zuo, Rui
RA   Ni, Nan
RA   Eilers, Grant
RA   Wu, Duo-Lin
RA   Pei, Yu-Ting
RA   Nie, Zuo-Ming
RA   Wu, Ye-Qing
RA   Wu, Yue-Hong
RA   Ou, Wen-Bin
RT   "Activated tyrosine kinases in gastrointestinal stromal tumor with
RT   loss of KIT oncoprotein expression.";
RL   Cell Cycle 17:2577-2592(2018).
//