Cellosaurus logo
expasy logo

Cellosaurus MCF-7 TTE-MBD2 (CVCL_A8P5)

[Text version]
Cell line name MCF-7 TTE-MBD2
Accession CVCL_A8P5
Resource Identification Initiative To cite this cell line use: MCF-7 TTE-MBD2 (RRID:CVCL_A8P5)
Comments Population: Caucasian.
Characteristics: The transfected human MBD2 gene is N-terminally tagged with a Ty1-Ty1-ER (TTE) epitope tag.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6917; MBD2.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
Omics: MBD2 ChIP-seq epigenome analysis.
Omics: Pol2 ChIP-seq epigenome analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=24927503; DOI=10.1371/journal.pone.0099603; PMCID=PMC4057170
Menafra R., Brinkman A.B., Matarese F., Franci G., Bartels S.J.J., Nguyen L., Shimbo T., Wade P.A., Hubner N.C., Stunnenberg H.G.
Genome-wide binding of MBD2 reveals strong preference for highly methylated loci.
PLoS ONE 9:E99603-E99603(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A8P5
Encyclopedic resources Wikidata; Q102114501
Gene expression databases GEO; GSM1322266
GEO; GSM1322268
GEO; GSM1322269
GEO; GSM1388122
GEO; GSM1388124
GEO; GSM1388125
GEO; GSM1388126
GEO; GSM1388127
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number9