Cellosaurus cell line UT-SCC-126A (CVCL

Cellosaurus UT-SCC-126A (CVCL_A7EC)

[Text version]

Cell line name

UT-SCC-126A

Synonyms

University of Turku-Squamous Cell Carcinoma-126A

Accession

CVCL_A7EC

Resource Identification Initiative

To cite this cell line use: UT-SCC-126A (RRID:CVCL_A7EC)

Comments

Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Oral cavity, lower lip; UBERON=UBERON_0001835.

Sequence variations

Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu130Phe (c.388C>T); ClinVar=VCV000216466; Zygosity=Heterozygous (PubMed=29970484).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu171Lys (c.511G>A); ClinVar=VCV000141566; Zygosity=Heterozygous (PubMed=29970484).

Disease

Oral cavity squamous cell carcinoma (NCIt: C4833)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

81Y

Category

Cancer cell line

STR profile

Source(s): PubMed=30135316

Markers:

Amelogenin	X
CSF1PO	10,13
D2S1338	19
D3S1358	16
D5S818	11,12
D7S820	10
D8S1179	13,14
D13S317	9,12
D16S539	12,13
D18S51	13
D19S433	14,15
D21S11	28,30
FGA	22
TH01	8,9
TPOX	9,11
vWA	17,18

Publications

PubMed=29970484; DOI=10.1158/1535-7163.MCT-17-0733
Lepikhova T., Karhemo P.-R., Louhimo R., Yadav B., Murumagi A., Kulesskiy E., Kivento M., Sihto H., Grenman R., Syrjanen S.M., Kallioniemi O.-P., Aittokallio T., Wennerberg K., Joensuu H., Monni O.
Drug-sensitivity screening and genomic characterization of 45 HPV-negative head and neck carcinoma cell lines for novel biomarkers of drug efficacy.
Mol. Cancer Ther. 17:2060-2071(2018)

PubMed=30135316; DOI=10.1172/jci.insight.122204; PMCID=PMC6141174
Jamieson S.M.F., Tsai P., Kondratyev M.K., Budhani P., Liu A., Senzer N.N., Chiorean E.G., Jalal S.I., Nemunaitis J.J., Kee D., Shome A., Wong W.W., Li D., Poonawala-Lohani N., Kakadia P.M., Knowlton N.S., Lynch C.R.H., Hong C.R., Lee T.W., Grenman R., Caporiccio L., McKee T.D., Zaidi M., Butt S., Macann A.M.J., McIvor N.P., Chaplin J.M., Hicks K.O., Bohlander S.K., Wouters B.G., Hart C.P., Print C.G., Wilson W.R., Curran M.A., Hunter F.W.
Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma.
JCI Insight 3:e122204.1-e122204.19(2018)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_A7EC

Encyclopedic resources

Wikidata; Q107117366

Gene expression databases

GEO; GSM2883398
GEO; GSM2888861

Entry history

Entry creation

20-May-2021

Last entry update

19-Dec-2024

Version number