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Cellosaurus SK-PN-LI (CVCL_A748)

[Text version]
Cell line name SK-PN-LI
Synonyms SK-PNET-Li; SKPNETLI
Accession CVCL_A748
Resource Identification Initiative To cite this cell line use: SK-PN-LI (RRID:CVCL_A748)
Comments Part of: MD Anderson Cell Lines Project.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis by RNAseq.
Sequence variations
  • Gene fusion; HGNC; 3446; ERG + HGNC; 3508; EWSR1; Name(s)=EWSR1-ERG, EWS-ERG (PubMed=8040301; PubMed=25010205).
  • Mutation; HGNC; 11355; STAG2; Simple; p.Ser704fs; Zygosity=Unspecified (PubMed=25010205).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val272Leu (c.814G>T); ClinVar=VCV000012358; Zygosity=Unspecified (PubMed=25010205).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (PubMed=25010205).
Disease Primitive neuroectodermal tumor (NCIt: C3716)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 3Y
Category Cancer cell line
STR profile Source(s): PubMed=25010205

Markers:
AmelogeninX,Y
CSF1PO10
D2S133817,21
D3S135815
D5S81812
D7S82010,12
D8S117912,14
D13S3179,11
D16S53912
D18S5116,20
D19S43314,16
D21S1133.2
FGA21,22
TH016,8
TPOX8,12
vWA14,18

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=2987426; DOI=10.1007/BF00165170
Helson L., Helson C.
Human neuroblastoma cells and 13-cis-retinoic acid.
J. Neurooncol. 3:39-41(1985)

PubMed=3024811; DOI=10.1016/0165-4608(87)90084-7
Potluri V.R., Gilbert F., Helsen C., Helson L.
Primitive neuroectodermal tumor cell lines: chromosomal analysis of five cases.
Cancer Genet. Cytogenet. 24:75-86(1987)

DOI=10.1016/B978-0-12-333530-2.50006-X
Israel M.A., Thiele C.J.
Tumor cell lines of the peripheral nervous system.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York (1994)

PubMed=8040301; DOI=10.1172/JCI117360
Giovannini M., Biegel J.A., Serra M., Wang J.-Y., Wei Y.-L.H., Nycum L., Emanuel B.S., Evans G.A.
EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations.
J. Clin. Invest. 94:489-496(1994)

PubMed=25010205; DOI=10.1371/journal.pgen.1004475
Brohl A.S., Solomon D.A., Chang W., Wang J.-J., Song Y., Sindiri S., Patidar R., Hurd L., Chen L., Shern J.F., Liao H.-L., Wen X.-Y., Gerard J., Kim J.-S., Lopez Guerrero J.A., Machado I., Wai D.H., Picci P., Triche T.J., Horvai A.E., Miettinen M.M., Wei J.S., Catchpoole D., Llombart-Bosch A., Waldman T., Khan J.
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:E1004475-E1004475(2014)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A748
Encyclopedic resources Wikidata; Q54954520
Polymorphism and mutation databases Cosmic; 1078389
Cosmic; 2228234
Entry history
Entry creation06-Jun-2012
Last entry update05-Oct-2023
Version number18